Complementary and alternative medicine use and substitution for conventional therapy by HIV-infected patients
Complementary and alternative medicine use and substitution for conventional therapy by HIV-infected patients
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艾滋病毒感染者使用辅助和替代药物及替代常规疗法的情况
DOI：
10.1097/00126334-200306010-00007
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发表时间：
2003-06-01
影响因子：
3.6
通讯作者：
Wenger, NS
中科院分区：
文献类型：
--
作者：
Hsiao, AF;Wong, MD;Wenger, NS
背景资料：HIV感染者通常使用补充和替代药物（CAM），但尚不清楚CAM作为常规HIV治疗的补充或替代药物的使用频率。目的：评估CAM使用的流行率和相关因素，以及潜在的不良反应和CAM替代常规HIV药物。设计和参与者：美国全国HIV感染者概率样本的横断面调查（2，466名成人）。主要结果变量：任何CAM使用，CAM使用可能产生不良反应，以及使用CAM作为常规HIV治疗的替代品。替代被定义为替换的一些或所有传统的艾滋病毒药物与CAM。结果：百分之五十三的患者最近使用至少一种类型的CAM。四分之一的患者使用CAM有潜在的不良反应，三分之一的患者没有与他们的医疗保健提供者讨论过这种使用。对医疗信息有更大需求、参与医疗决策以及对抗逆转录病毒药物持消极态度的患者更有可能使用CAM。3%的患者用CAM替代传统的HIV治疗。他们更愿意参与医疗决策（比值比，1.8; 95%置信区间，1.0-3.2）和对抗逆转录病毒药物持消极态度（比值比，7.8; 95%可信区间，3.0-19.0）。医生应该公开询问HIV感染者关于CAM的使用，以防止不良反应，并确定CAM替代传统的HIV治疗。
Background: HIV-infected patients commonly use complementary and alternative medicine (CAM), but it is not known how often CAM is used as a complement or as a substitute for conventional HIV therapy.Objectives: To evaluate the prevalence and factors associated with CAM use with potential for adverse effects and CAM substitution for conventional HIV medication.Design and Participants: Cross-sectional survey of U.S. national probability sample of HIV-infected patients (2,466 adults) in care from December 1996 to July 1997.Main Outcome Variables: Any CAM use, CAM use with potential for adverse effects, and use of CAM as a substitute for conventional HIV therapy. Substitution was defined as replacement of some or all conventional HIV medications with CAM.Results: Fifty-three percent of patients had recently used at least one type of CAM. One quarter of patients used CAM with the potential for adverse effects, and one-third had not discussed such use with their health care provider. Patients with a greater desire for medical information and involvement in medical decision making and with a negative attitude toward antiretrovirals were more likely to use CAM. Three percent of patients substituted CAM for conventional HIV therapy. They were more likely to desire involvement in medical decision-making (odds ratio, 1.8; 95% confidence interval, 1.0-3.2) and to have a negative attitude toward antiretrovirals (odds ratio, 7.8; 95% confidence interval, 3.0-19.0).Conclusions: Physicians should openly ask HIV-infected patients about CAM use to prevent adverse effects and to identify CAM substitution for conventional HIV therapy.