Estimating a preference-based single index for the Impact of Weight on Quality of Life-Lite (IWQOL-lite) instrument from the SF-6D
Estimating a preference-based single index for the Impact of Weight on Quality of Life-Lite (IWQOL-lite) instrument from the SF-6D
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DOI：
10.1111/j.1524-4733.2004.74012.x
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发表时间：
2004-07-01
期刊：
影响因子：
4.5
通讯作者：
Williams, GR
中科院分区：
文献类型：
--
作者：
Brazier, JE;Kolotkin, RL;Williams, GR
目的：为了便于对治疗肥胖的干预措施进行经济评估，我们估计了一个基于偏好的单一指数，即体重对生活质量的影响--通过将其映射到SF-6D基于偏好的指数上，来使用IWQOL-lite仪器。1972名个体的异质样本，由社区志愿者和减肥计划、临床试验和胃旁路研究的参与者组成，完成了IWQOL-lite（一种肥胖特异性健康相关生活质量（HRQOL）指标）和SF-36（一种转换为基于偏好的SF-6D的HRQOL通用指标）。结果：预测SF-6D各指标得分的最佳拟合模型以各项目的水平为自变量（交叉验证样本中R-2 = 0.530，平均绝对误差为0.0976）。该模型（1）比使用总分、维度得分或项目得分作为因变量的模型做出更少的假设，（2）提供了来自IWQOL-Lite数据的基于偏好的指数的稳健无偏估计，其中未使用基于偏好的测量。年龄和体重指数（BMI）的增加导致了轻微的改善model.Conclusions：这是可能的，以促进经济评价使用特定疾病的工具，使用这种方法获得的结果。这种方法的一个弱点是，可能有一些方面的条件，尚未适当反映在SF-6D指数。不过，在尚未实行优惠措施和进行全面估值调查不切实际的情况下，这一办法是有用的。
Objective: To facilitate economic evaluations of interventions for treating obesity, we estimated a preference-based single index for the Impact of Weight on Quality of Life-Lite (IWQOL-lite) instrument by mapping it onto the SF-6D preference-based index.Methods: A heterogeneous sample of 1972 individuals, composed of community volunteers and participants in weight loss programs, clinical trials, and gastric bypass studies, completed the IWQOL-lite, an obesity-specific measure of health-related quality of life (HRQOL), and the SF-36, a generic measure of HRQOL converted into the preference-based SF-6D. Models of the relationship between the IWQOL-lite and SF-6D of increasing complexity were estimated by regression analyses.Results: The best fitting model for predicting SF-6D index scores entered levels for each item as independent variables (R-2 = 0.530 in the cross-validation sample, with a mean absolute error of 0.0976). This model (1) makes fewer assumptions than those using total score, dimension scores or item scores as dependent variables and (2) provides a robust unbiased estimate of a preference-based index from IWQOL-Lite data where a preference-based measure was not used. The addition of age and body mass index (BMI) led to a slight improvement in the model.Conclusions: It is possible to facilitate economic evaluations using results obtained from disease-specific instruments using this approach. A weakness of this approach is that there may be aspects of the condition that have not been properly reflected in the SF-6D index. It is, however, useful when a preference-based measure has not been administered and when it would be impractical to conduct a full valuation survey.