Deformation Mechanisms of “Two-Part” Natural Adhesive in Bone Interfibrillar Nano-Interfaces
Deformation Mechanisms of “Two-Part” Natural Adhesive in Bone Interfibrillar Nano-Interfaces
复制标题
骨纤维间纳米界面“双组分”天然粘合剂的变形机制
DOI：
10.1021/acsbiomaterials.9b00588
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发表时间：
2018
影响因子：
5.8
通讯作者：
Minary-Jolandan, Majid
中科院分区：
文献类型：
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作者：
Morsali, Reza;Dai, Zhengwei;Wang, Yang;Qian, Dong;Minary-Jolandan, Majid
骨中纳米级界面处的非胶原蛋白按重量计小于骨含量的2-3%，而它们对断裂韧性的贡献超过30%。非胶原蛋白在纤维间界面中的作用的定量理解的主要差距，主要是因为探测其纳米尺度的限制，导致了持续的争议和几个突出的假设，他们的作用和功能，可以追溯到几个世纪前伽利略的原始工作。我们的研究结果从第一个详细的计算模型的纳米界面在骨揭示“协同”变形机制的“双部分”天然胶，即，非胶原骨桥蛋白和骨钙素在纤维间界面。具体地说，通过强锚定和矿物纳米片上的动态结合位点的形成，纳米界面可以维持大的非线性变形，延性接近5000%。这种大的变形导致超过10350 J/g的突出的比断裂能，这大于最已知的坚韧材料（例如Kevlar、蜘蛛丝等）。
Noncollagenous proteins at nanoscale interfaces in bone are less than 2–3% of bone content by weight, while they contribute more than 30% to fracture toughness. Major gaps in quantitative understanding of noncollagenous proteins’ role in the interfibrillar interfaces, largely because of the limitation of probing their nanoscale dimension, have resulted in ongoing controversies and several outstanding hypotheses on their role and function, arguably going back to centuries ago to the original work from Galileo. Our results from the first detailed computational model of the nano-interface in the bone reveal “synergistic” deformation mechanism of a “double-part” natural glue, that is, noncollagenous osteopontin and osteocalcin at the interfibrillar interface. Specifically, through strong anchoring and formation of dynamic binding sites on mineral nanoplatelets, the nano-interface can sustain a large nonlinear deformation with ductility approaching 5000%. This large deformation results in an outstanding specific energy to failure exceeding ∼350 J/g, which is larger than the most known tough materials (such as Kevlar, spider silk, and so forth.).