Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction
Quantifying parenchymal tethering in a finite element simulation of a human lung slice under bronchoconstriction
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DOI：
10.1016/j.resp.2012.06.014
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发表时间：
2012-08-15
影响因子：
2.3
通讯作者：
Tawhai, Merryn H.
中科院分区：
文献类型：
--
作者：
Breen, Barbara J.;Donovan, Graham M.;Tawhai, Merryn H.
气道高反应性（AHR）是哮喘的一个标志，是一种高度复杂的现象，其特征是在大范围的长度和时间尺度上表现为多个过程。推导了多尺度计算模型，以体现对AHR的实验理解。虽然目前的模型在推导上存在差异，但一个普遍的假设是，气道收缩期间实质系索压力P-teth的增加可以用Lai-Fook（1979）提出的模型来描述，该模型基于完整的肺弹性模量实验数据，该数据在一定的膨胀压力范围内。在这里，我们重新检查了这种关系与非线性弹性材料定律的一致性，该定律已参数化为完整肺的压力-体积行为。结果表明，在小约束条件下，非线性律和Lai-Fook关系是一致的，而当约束条件变大时，非线性律和Lai-Fook关系是发散的。(c) 2012 Elsevier B.V.版权所有
Airway hyper-responsiveness (AHR), a hallmark of asthma, is a highly complex phenomenon characterised by multiple processes manifesting over a large range of length and time scales. Multiscale computational models have been derived to embody the experimental understanding of AHR. While current models differ in their derivation, a common assumption is that the increase in parenchymal tethering pressure P-teth during airway constriction can be described using the model proposed by Lai-Fook (1979), which is based on intact lung experimental data for elastic moduli over a range of inflation pressures. Here we reexamine this relationship for consistency with a nonlinear elastic material law that has been parameterised to the pressure-volume behaviour of the intact lung. We show that the nonlinear law and Lai-Fook's relationship are consistent for small constrictions, but diverge when the constriction becomes large. (c) 2012 Elsevier B.V. All rights reserved.