Trends in Basal Cell Carcinoma Incidence and Identification of High-Risk Subgroups, 1998-2012
Trends in Basal Cell Carcinoma Incidence and Identification of High-Risk Subgroups, 1998-2012
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DOI：
10.1001/jamadermatol.2015.1188
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发表时间：
2015-09-01
期刊：
影响因子：
10.9
通讯作者：
Quesenberry, Charles P.
中科院分区：
文献类型：
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作者：
Asgari, Maryam M.;Moffet, Howard H.;Quesenberry, Charles P.
重要性 基底细胞癌 (BCC) 的发病率在全球范围内不断增加，但美国的发病率很难量化，因为 BCC 不是可报告的肿瘤。 目的 按年龄、性别和种族/族裔估计年度 BCC 发病率，以确定人口统计学上不同的高风险亚组并评估发病率随时间的变化。 设计、设置和参与者 在这项回顾性队列研究中（1 月 1 日， 1998 年至 2012 年 12 月 31 日），我们研究了北加州 Kaiser Permanente 的 147 093 名 BCC 患者，该系统是一个大型综合医疗保健提供系统，使用先前经过验证的 BCC 登记系统进行识别。 主要结果和测量 我们按年龄、性别和种族/民族估计了年度 BCC 发病率，并评估了发病率随时间的变化。 BCC 发病率根据 2010 年美国人口普查人口的年龄、性别和种族/民族分布进行标准化。 结果 在调整年龄、性别和种族的模型中，男性患者的发病率高于女性患者（发病率比 [IRR]，1.65；95% CI，1.60-1.70）。 65至79岁和80岁及以上的人的发病率高于40至64岁的人（IRR，2.96；95% CI，2.86-3.06；IRR，5.14；95% CI，4.94-5.35）。白人的发病率高于多种族人士（IRR，1.96；95% CI，1.80-2.13）、西班牙裔（IRR，8.56；95% CI，7.79-9.41）、亚洲人（IRR，33.13；95% CI，27.84-39.42）和黑人（IRR，72.98；95% CI，27.84-39.42）。 95% CI, 49.21-108.22）。结论和相关性 我们估计每年大约有 200 万美国人患有 BCC。我们的研究结果提供了对基底细胞癌发病率的最新估计，强调了不断变化的流行病学发现，并更好地识别人口统计学上不同的高风险亚组。
IMPORTANCE The incidence of basal cell carcinomas (BCCs) is increasing globally, but incidence rates in the United States are difficult to quantify because BCCs are not reportable tumors.OBJECTIVE To estimate annual BCC incidence rates by age, sex, and race/ethnicity to identify demographically distinct high-risk subgroups and to assess changes in rates over time.DESIGN, SETTING, AND PARTICIPANTS In this retrospective cohort study (January 1, 1998, through December 31, 2012), we studied 147 093 patients with BCC from Kaiser Permanente Northern California, a large, integrated health care provision system, identified using a previously validated BCC registry.MAIN OUTCOMES AND MEASURES We estimated annual BCC incidence rates by age, sex, and race/ethnicity and assessed changes in rates over time. The BCC incidence rates were standardized to the age, sex, and race/ethnicity distribution of the 2010 US Census population.RESULTS In models adjusting for age, sex, and race, male patients had higher rates than female patients (incidence rate ratio [IRR], 1.65; 95% CI, 1.60-1.70). Persons 65 through 79 years of age and those 80 years and older had higher rates than persons 40 through 64 years of age (IRR, 2.96; 95% CI, 2.86-3.06; and IRR, 5.14; 95% CI, 4.94-5.35, respectively). Whites had higher rates than multiracial persons (IRR, 1.96; 95% CI, 1.80-2.13), Hispanics (IRR, 8.56; 95% CI, 7.79-9.41), Asians (IRR, 33.13; 95% CI, 27.84-39.42), and blacks (IRR, 72.98; 95% CI, 49.21-108.22).CONCLUSIONS AND RELEVANCE We estimate that BCCs occur in approximately 2 million Americans annually. Our findings provide an updated estimate of the incidence of BCCs, highlight the changing epidemiologic findings, and better identify demographically distinct high-risk subgroups.