Genetic mediation of the associations among motor and perceptual speed and adult cognitive abilities
Genetic mediation of the associations among motor and perceptual speed and adult cognitive abilities
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DOI：
10.1076/1382-5585(200009)7:3;1-q;ft141
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发表时间：
2000-09-01
影响因子：
1.9
通讯作者：
Harris, JR
中科院分区：
文献类型：
--
作者：
Finkel, D;Pedersen, NL;Harris, JR
进行定量遗传分析以确定正常衰老过程中运动速度、知觉速度和认知能力之间关联的遗传调节。瑞典收养/双胞胎衰老研究提供了四个领域（结晶、流体、空间和记忆）的运动表现、感知速度和认知功能的测量结果。样本包括 206 对双胞胎，年龄从 44 岁到 83 岁不等。电机速度系数是根据电机性能的 17 个定时测量值构建的。中年双胞胎的运动速度遗传力为 0.26，老年双胞胎的运动速度遗传力为 0.00。结果表明，中年队列中认知功能的遗传变异可能由工作记忆来定义，而老年队列中的遗传变异则由知觉速度来定义。运动速度、知觉速度和空间能力之间的关联中存在非共享环境成分的迹象表明可能涉及额叶。
Quantitative genetic analyses were conducted to determine the genetic mediation of the associations among motor speed, perceptual speed, and cognitive abilities in normal aging. Measures of motor performance, perceptual speed, and cognitive functioning in four domains (crystallized, fluid, spatial, and memory) were available from the Swedish Adoption/Twin Study of Aging. The sample included 206 twin pairs ranging in age from 44 to 83 years. A Motor Speed factor was constructed from 17 timed measures of motor performance. Heritability of Motor Speed was .26 in middle-aged twins and .00 in older twins. Results indicated that genetic variance in cognitive functioning in the middle-aged cohort may be defined by working memory, whereas genetic variance in the older cohort was defined by perceptual speed. Indications of a nonshared environmental component in the association among motor speed, perceptual speed, and spatial abilities suggest possible frontal lobe involvement.