Contact Lens‐Induced Corneal Epithelial Injury
Contact Lens‐Induced Corneal Epithelial Injury
复制标题
隐形眼镜引起的角膜上皮损伤
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
L. W. Chu
中科院分区：
文献类型：
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作者：
J. Bergmanson;L. W. Chu
摘要在灵长类动物身上配戴硬性隐形眼镜，以研究随后的角膜上皮损伤。这一创伤被比作钝物造成的角膜擦伤。创伤性擦伤导致基底层细胞破裂，基底层细胞被认为是角膜上皮细胞中最脆弱的部分。基底细胞的内质膜因细胞膜上有较强的半桥粒而与上皮基底膜粘连。隐形眼镜能够产生类似的损伤，不会穿透基底膜，因此不会涉及前限板(鲍曼膜)。我们得出的结论是，隐形眼镜会产生自限性创伤，甚至会导致严重的隐形眼镜过度佩戴，尽管它会导致角膜深度擦伤，但很少会导致永久性疤痕形成。
Abstract Rigid contact lenses were fitted on primates to study the subsequent corneal epithelial injury. This trauma was compared to corneal abrasions produced by a blunt object. The traumatic abrasion caused a rupture of the basal cells, which were identified as the most vulnerable part of the corneal epithelium for such an injury. The internal plasmalemma of the basal cell remained adherent to the epithelial basement membrane due to the strong hemidesmosomes along the cell membrane. Contact lenses were capable of producing similar injuries which did not penetrate the basement membrane and therefore did not involve the anterior limiting lamina (Bowman's membrane). We concluded that contact lenses produce a self‐limiting trauma and even a severe case of contact lens overwear, although it causes deep corneal abrasions, seldom results in permanent scar formation.