Maternal HIV Infection and Antibody Responses Against Vaccine-Preventable Diseases in Uninfected Infants
Maternal HIV Infection and Antibody Responses Against Vaccine-Preventable Diseases in Uninfected Infants
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DOI：
10.1001/jama.2011.100
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发表时间：
2011-02-09
影响因子：
120.7
通讯作者：
Hesseling, Anneke C.
中科院分区：
文献类型：
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作者：
Jones, Christine E.;Naidoo, Shalena;Hesseling, Anneke C.
免疫反应的改变可能导致人类免疫缺陷病毒（HIV）暴露的未感染婴儿的高发病率和死亡率。目的研究母体HIV感染与母婴乙型流感嗜血杆菌（Hib）、肺炎球菌、百日咳杆菌抗原、破伤风类毒素和乙型肝炎表面抗原特异性抗体水平的关系。2009年3月3日至2010年4月28日，在南非西开普省Khayelitsha进行了一项基于社区的队列研究，对109名艾滋病毒感染和未感染的妇女及其婴儿进行了研究。在出生时收集了104名妇女和100名婴儿的血清样本，并在16周时收集了93名婴儿的样本。主要结局指标：通过酶联免疫吸附试验测定分娩时母婴对和16周婴儿的特异性抗体水平。结果出生时，hiv暴露的未感染婴儿（n=46）对Hib的特异性抗体水平低于未暴露婴儿（n=54）(0.37[四分位数区间{IQR}， 0.22-0.67] mg/L vs 1.02 [IQR}, 0.34-3.79] mg/L
Context Altered immune responses might contribute to the high morbidity and mortality observed in human immunodeficiency virus (HIV)-exposed uninfected infants.Objective To study the association of maternal HIV infection with maternal-and infant-specific antibody levels to Haemophilus influenzae type b (Hib), pneumococcus, Bordetella pertussis antigens, tetanus toxoid, and hepatitis B surface antigen.Design, Setting, and Participants A community-based cohort study in Khayelitsha, Western Cape Province, South Africa, between March 3, 2009, and April 28, 2010, of 109 HIV-infected and uninfected women and their infants. Serum samples from 104 women and 100 infants were collected at birth and samples from 93 infants were collected at 16 weeks.Main Outcome Measure Level of specific antibody in mother-infant pairs at delivery and in infants at 16 weeks, determined by enzyme-linked immunosorbent assays.Results At birth, HIV-exposed uninfected infants (n=46) had lower levels of specific antibodies than unexposed infants (n=54) did to Hib (0.37 [interquartile range {IQR}, 0.22-0.67] mg/L vs 1.02 [IQR, 0.34-3.79] mg/L; P