Local translation in neuronal processes
Local translation in neuronal processes
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DOI：
10.1016/j.conb.2019.02.008
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发表时间：
2019-08-01
影响因子：
5.7
通讯作者：
Schuman, Erin M.
中科院分区：
文献类型：
--
作者：
Biever, Anne;Donlin-Asp, Paul G.;Schuman, Erin M.
神经元表现出独特的空间区室化程度，能够独立于细胞体维持和重塑其蛋白质组。虽然已经投入了大量的努力来了解树突和棘中局部蛋白质合成的能力和作用，但成熟轴突中的局部mRNA翻译（投射距离可达一米）受到的关注要少得多。此外，很少有人知道轴突和树突基因表达的时空动态的mRNA丰度，蛋白质合成和降解的功能。在这里，我们总结了最近的关键发现，塑造了我们的知识的精确位置的本地蛋白质生产和讨论独特的策略，神经元形状突触前和突触后蛋白质组。
Neurons exhibit a unique degree of spatial compartmentalization and are able to maintain and remodel their proteomes independently from the cell body. While much effort has been devoted to understanding the capacity and role for local protein synthesis in dendrites and spines, local mRNA translation in mature axons, projecting over distances up to a meter, has received much less attention. Also, little is known about the spatio-temporal dynamics of axonal and dendritic gene expression as function of mRNA abundance, protein synthesis and degradation. Here, we summarize key recent findings that have shaped our knowledge of the precise location of local protein production and discuss unique strategies used by neurons to shape presynaptic and postsynaptic proteomes.