Issues related to botanicals
Issues related to botanicals
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DOI：
10.1016/j.lfs.2005.12.019
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发表时间：
2006-03-27
期刊：
影响因子：
6.1
通讯作者：
Khan, IA
中科院分区：
文献类型：
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作者：
Khan, IA
草药产品研究不能被认为是科学有效的，如果被测试的产品没有经过认证和表征，以确保有关产品生产的可重复性。许多研究都是指标准化材料的使用，但实际上是指化学标准化。虽然化学标准化很重要，但当起始原料没有很好地植物学表征时，它的效用是有限的。虽然结果研究相对于实际测试产品是合理的，但产品的充分认证无法与市场上的其他产品进行比较。此外，由于植物基质的身份不一致，无法对一项研究与另一项研究进行比较。田间植物材料认证所需的工具也取决于所涉及的植物和过程。这可以像植物学/形态学鉴定一样简单，也可以像遗传或化学分析一样复杂。经过认证的原料是植物产品开发的基本起点。然而，收获、储存、加工和配制方法可能会改变所需的标记成分或增加不需要的污染物的可能性，从而极大地影响最终产品的质量和一致性。因此，经过验证的方法来确保生产和储存过程中的质量控制是确保产品最佳功效和安全性的必要工具。这些控制对于植物补充剂的药理学、毒理学和临床研究的评估也是至关重要的。(c) 2006爱思唯尔公司所有航班预订。
Herbal product studies cannot be considered scientifically valid if the product tested was not authenticated and characterized in order to ensure reproducibility in the manufacturing of the product in question. Many studies refer to the use of standardized material, but in reality they are referring to chemical standardization. While chemical standardization is important, its utility is limited when the starting material is not well characterized botanically. Although the resulting studies are sound with respect to the actual product tested, adequate authentication of the product cannot be compared to other products on the market. Also, a comparison of one study to another cannot be made due to inconsistencies in the identity of the botanical matrix. The tools needed for authentication of the field plant material also depend on the plant and process involved. This could be as straightforward as botanical/morphological identification or as elaborate as genetic or chemical profiling. Authenticated raw material is the basic starting point for the development of a botanical product. However, harvesting, storing, processing and formulating methods may dramatically affect the quality and consistency of the final product by altering the desired marker components or by increasing the possibility of unwanted contaminants. Thus, validated methods to ensure quality control in manufacturing and storage are required tools for optimal efficacy and safety of the products. These controls are also critical for the evaluation of pharmacological, toxicological and clinical studies of the botanical supplements. (c) 2006 Elsevier Inc. All fights reserved.