The Importance of the Biological Impact of Exposure to the Concept of the Exposome.
The Importance of the Biological Impact of Exposure to the Concept of the Exposome.
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DOI：
10.1289/ehp140
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发表时间：
2016-10
影响因子：
10.4
通讯作者：
Miller GW
中科院分区：
文献类型：
--
作者：
Dennis KK;Auerbach SS;Balshaw DM;Cui Y;Fallin MD;Smith MT;Spira A;Sumner S;Miller GW
“麻烦”一词最初是在2005年创造的，定义为整个生命周期的暴露总量。该系统为研究人类健康和疾病提供了一个极好的科学框架。最近，有人提出，暴露如何影响我们的生物学以及我们的身体如何对这种暴露做出反应应该是麻烦的一部分。作者描述了该基因组的生物学影响，并概述了许多目标和过程，这些目标和过程可以作为该基因组综合分析的一部分进行评估。与外源性和内源性化合物最初相互作用的下游过程决定了接触的生物影响。如果不将影响与接触放在同一背景下考虑，就很难确定因果关系。麻烦组和生物学是相互作用的--由于环境改变了一个人对随后暴露的脆弱性而引起的生物学变化。此外，高弹性的个人能够承受环境暴露，对他们的健康影响最小。我们预计，绝大多数接触是短暂的，几周、几个月或几年前发生的化学物质早就从体内消失了。然而，这些过去的化学品暴露往往会留下分子指纹，这些指纹可能能够提供关于这些过去暴露的信息。通过将暴露与特定的生物反应联系起来，棘手的研究可以有助于提高对暴露与健康之间的机械联系的理解，以帮助减轻整个生命周期的不良健康后果。丹尼斯KK，奥尔巴赫SS，巴尔肖DM，崔Y，Fallin MD，史密斯MT，斯皮拉A，萨姆纳S，米勒GW。2016.暴露于干扰素组概念的生物学影响的重要性。环境健康展望124：1504-1510; http：dx.doi.org/10.1289/EHP140
The term “exposome” was originally coined in 2005 and defined as the totality of exposures throughout the lifetime. The exposome provides an excellent scientific framework for studying human health and disease. Recently, it has been suggested that how exposures affect our biology and how our bodies respond to such exposures should be part of the exposome. The authors describe the biological impact of the exposome and outline many of the targets and processes that can be assessed as part of a comprehensive analysis of the exposome. The processes that occur downstream from the initial interactions with exogenous and endogenous compounds determine the biological impact of exposures. If the effects are not considered in the same context as the exposures, it will be difficult to determine cause and effect. The exposome and biology are interactive—changes in biology due to the environment change one’s vulnerability to subsequent exposures. Additionally, highly resilient individuals are able to withstand environmental exposures with minimal effects to their health. We expect that the vast majority of exposures are transient, and chemicals underlying exposures that occurred weeks, months, or years ago are long gone from the body. However, these past chemical exposures often leave molecular fingerprints that may be able to provide information on these past exposures. Through linking exposures to specific biological responses, exposome research could serve to improve understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the lifespan. Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW. 2016. The importance of the biological impact of exposure to the concept of the exposome. Environ Health Perspect 124:1504–1510; http://dx.doi.org/10.1289/EHP140