Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline
Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline
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DOI：
10.1016/j.bbi.2019.09.001
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发表时间：
2019-11-01
影响因子：
15.1
通讯作者：
Gray, Laura
中科院分区：
文献类型：
--
作者：
Hasebe, Kyoko;Rivera, Leni R.;Gray, Laura
米诺环素是一种新兴的治疗抑郁症的新型药物，它有可能同时影响肠道微生物群和炎症状态。本研究表明，慢性高脂饮食喂养导致雄性小鼠的行为和肠道微生物群的变化，而没有明显的炎症反应。饮食引起的行为变化的特征是在强迫游泳试验中增加了不动，在野外试验中改变了活动能力。米诺环素显著改变了肠道微生物群，使群落与未经治疗的健康和受饮食影响的状态截然不同。相比之下，米诺环素并不能逆转高脂饮食引起的行为变化。
An emerging novel therapeutic agent for major depressive disorder, minocycline, has the potential to influence both gut microbiome and inflammatory status. The present study showed that chronic high fat diet feeding led to changes in both behaviour and the gut microbiome in male mice, without an overt inflammatory response. The diet-induced behavioural changes were characterised as increased immobility in the forced swim test and changes in locomotor activities in the open field test. Minocycline significantly altered the gut microbiome, rendering a community distinctly different to both untreated healthy and diet-affected states. In contrast, minocycline did not reverse high fat diet-induced changes in behaviour.