Rapid actions of insulin on sensory nerve function
Rapid actions of insulin on sensory nerve function
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DOI：
10.1097/00001756-199808240-00017
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发表时间：
1998-08-24
期刊：
影响因子：
1.7
通讯作者：
de Courten, MP
中科院分区：
文献类型：
--
作者：
Delaney, CA;Murchie, KJ;de Courten, MP
用离子导入法研究了胰岛素对神经原性闪光的急性作用。25例胰岛素依赖型糖尿病（IDDM）患者和25名年龄和性别匹配的对照进行了研究。轴突反射血管舒张诱发的乙酰胆碱（ACh）的经皮离子导入之前和之后的皮肤治疗的离子导入胰岛素和测量使用激光多普勒测速仪。与对照组相比，IDDM患者的轴突反射反应降低（p 0.05）。这项研究证实了减少乙酰胆碱诱导的耀斑在人类患者的胰岛素依赖型糖尿病，并已证明了相对快速的影响，胰岛素对这种皮肤神经源性反应。(C)1998年利平科特威廉姆斯&威尔金斯。
THE acute action of insulin on neurogenic flare was investigated using iontophoresis. Twenty-five patients with insulin-dependent diabetes mellitus (IDDM) and 25 age- and gender-matched controls were studied. Axon reflex vasodilatation was evoked by transdermal iontophoresis of acetylcholine (ACh) before and after skin treatment by the iontophoresis of insulin and measured using laser Doppler velocimetry. Axon reflex responses were reduced in IDDM patients compared with controls (p 0.05). This study confirms the reduction of the ACh-induced flare in human patients with IDDM and has demonstrated relatively rapid effects of insulin on this cutaneous neurogenic response. (C) 1998 Lippincott Williams & Wilkins.