Toll-like Receptors and Diabetes Complications: Recent Advances
Toll-like Receptors and Diabetes Complications: Recent Advances
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DOI：
10.2174/157339912803529887
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发表时间：
2012-01-01
影响因子：
3.3
通讯作者：
Dasu, Mohan Ravi Krishna
中科院分区：
文献类型：
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作者：
Ramirez, Sandra Rosa;Dasu, Mohan Ravi Krishna
糖尿病（DM）是一种代谢异常导致衰弱并发症的疾病。2000年，全球糖尿病患病率为2.8%（1.71亿人），到2030年估计为4.4%（3.66亿人）。糖尿病是心脏、肾脏疾病和下肢截肢的主要危险因素。体外和体内数据表明，全身性炎症通过先天免疫受体在糖尿病并发症的发病机制中起作用。toll样受体（TLRs）是介导糖尿病炎症反应的关键先天免疫受体。目前还没有综述集体总结和研究TLRs在糖尿病并发症（心脏病、肾病、神经病变和伤口愈合）表现中的有害作用。因此，在这篇综述中，我们将总结TLR的表达和激活，并阐明它们在糖尿病并发症中炎症传播中的作用。
Diabetes mellitus (DM) is a disease with constellation of metabolic aberrations resulting in debilitating complications. The prevalence of DM worldwide was 2.8% (171 million people) in 2000 and estimated to be at 4.4% (366 million people) in 2030. DM is a major risk factor for heart, kidney diseases, and lower limb amputations. Emerging in vitro and in vivo data suggest that systemic inflammation plays a role in the pathogenesis of DM complications via innate immune receptors. Toll-like receptors (TLRs) are key innate immune receptors that mediate the inflammatory responses in DM. There are no reviews that collectively summarize and examine the detrimental role of TLRs in the manifestation of DM complications namely heart disease, nephropathy, neuropathy, and wound healing. Thus, in this review, we will provide summaries of the TLR expression and activation and elucidate their role in propagating inflammation seen in DM complications.