After-effects of a high altitude expedition on blood
After-effects of a high altitude expedition on blood
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DOI：
10.1055/s-2007-972616
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发表时间：
1997-04-01
影响因子：
2.5
通讯作者：
Kubanek, B
中科院分区：
文献类型：
--
作者：
Boning, D;Maassen, N;Kubanek, B
本研究的目的是探讨高原习服引起的血液变化，这些变化在返回后持续几天以上，并可能在海平面运动表现中发挥作用。在喜马拉雅山探险（26-29天，海拔4900至7600米）之前，期间和7/8或11/12天后，在12名登山者进行测量。[促红细胞生成素]仅在海拔高度暂时升高（最大值）。+ 11 +/- 1 [SE] mu/ml血清）。返回后，血红蛋白质量（最初为881 +/- 44 g，CO-Hb法）增加了14%（p < 0.01）;红细胞中天冬氨酸转氨酶活性（最初为682 +/- 25 U/l）增加（第7天：+ 964 +/- 152 U/l，第11天：+ 533 +/- 107 U/l），表明平均细胞年龄降低。计算的血容量（+ 14%）受海拔高度红细胞形成的影响，但也受海平面血浆扩张的影响。Hb-O-2（pH 7.4，37 ℃）的半饱和压力以及2，3-二磷酸甘油酸浓度最初已经很高（32.1 +/- 0.5 mmHg，20.5 +/- 0.7 μ mol/g Hb），并且在返回后仅显示出不显著的增加趋势。此外希尔的n是一贯高的登山运动员，而玻尔系数略有增加后才下降。可能是准备的体育训练，部分在阿尔卑斯山，并留在喜马拉雅山影响O-2亲和力很长一段时间。这些适应性变化可能是高原训练效应的一部分，从而降低了高原运动员体能的波动。
The aim of the study was to investigate blood alterations caused by altitude acclimatization which last more than few days after return and might play a role for exercise performance at sea level. Measurements were performed in 12 mountaineers before, during and either 7/8 or 11/12 days after a Himalaya expedition (26-29 days at 4900 to 7600 m altitude). [Erythropoietin] rose only temporarily at altitude (max. + 11 +/- 1 [SE] mu/ml serum). After return hemoglobin mass (initially 881 +/- 44 g, CO-Hb method) was increased by 14% (p < 0.01); aspartate aminotransferase activity in erythrocytes (initially 682 +/- 25 U/l) was augmented (day 7: + 964 +/- 152 U/l, day 11: + 533 +/- 107 U/l) indicating reduced mean cell age. Calculated blood volume (+ 14%) was influenced by red cell formation at altitude but also by plasma expansion at sea level. The half saturation pressure for Hb-O-2 (pH 7.4, 37 degrees C) as well as the 2,3-diphosphoglycerate concentration were already initially high (32.1 +/- 0.5 mmHg, 20.5 +/- 0.7 mu mol/g Hb) and showed only a nonsignificant tendency to increase after return. Also Hill's n was consistently high in the mountaineers, whereas the Bohr coefficients were slightly increased only after descent. Probably the preparatory physical training, partly in the Alps, and the stay in the Himalaya influenced O-2-affinity for a prolonged time. The adaptations might reduce the toss of physical performance capacity at altitude and be part of altitude training effects.