The Correlation Between Nasal Symptom and Mucociliary Clearance in Allergic Rhinitis

The Correlation Between Nasal Symptom and Mucociliary Clearance in Allergic Rhinitis
复制标题

DOI：
10.1002/lary.20146
复制
发表时间：
2009-08-01
期刊：
LARYNGOSCOPE
影响因子：
2.6
通讯作者：
Ruttanaphol, Suwalee
Ruttanaphol, Suwalee
中科院分区：
医学2区
文献类型：
--
作者：
Kirtsreesakul, Virat;Somjareonwattana, Pornpanitan;Ruttanaphol, Suwalee

文献摘要

被引文献

相似文献

目的/假设：变应性鼻炎及其对哮喘的影响(ARIA)变应性鼻炎(AR)的分类是基于鼻部症状的严重程度和持续时间。鼻部症状是否代表潜在的鼻部炎症尚不清楚。研究设计：前瞻性横断面研究。方法：73例AR患者按ARIA分级分为轻度或中重度间歇性AR(MIAR或MSIAR)和轻度或中度-重度持续性AR(MPAR或MSPAR)。每种鼻部症状的严重程度评分为1~3分(轻度-中度-重度)。鼻部症状评分之和即为总症状评分(TSS)。MCCT测定采用-炭-糖精法。比较ARIA、ARIA、MCCT三个级别的MCCT，并分析TSS或天数与每周症状评分(DSW)和MCCT的相关性。结果：中重度占67.1%。MSPAR的MCCT最差，其次是MSIAR、MPAR和MIAR(平均MCCT分别为14.32、13.87、11.94和10.28分钟)。TSS与MCCT呈正相关(P=.538，P&lt；.001)。Dsw与MCCT也呈正相关，但无统计学意义(r=0.217，P=0.065)。总体鼻部症状的平均MCCT随着评分的递增而增加，2分和3分之间差异有统计学意义(P&t；.001)。结论：该疾病严重组中中重度疾病所占比例较高，且与病情严重程度显著相关，且具有重要的异质性。区分中度和重度鼻炎应该有助于获得同质人群，并制定改进的疾病管理策略。
Objective/Hypothesis: The Allergic Rhinitis and Its Impact on Asthma (ARIA) classification of allergic rhinitis (AR) is based on the severity and duration of nasal symptoms. Whether the nasal symptoms actually represent underlying nasal inflammation is unclear. The aim of this study was to evaluate the correlation between nasal symptoms and nasal inflammation using mucociliary clearance time (MCCT) in AR.Study Design: A prospective cross-sectional study.Methods: 73 AR patients were classified according to ARIA class: mild or moderate-severe intermittent AR (MIAR or MSIAR) and mild or moderate-severe persistent AR (MPAR or MSPAR). Each nasal Symptom was scored as 1 to 3 on a severity scale (mild-moderate-severe). The sum of the individual nasal symptom scores gave the total symptoms score (TSS). MCCT was determined with the-charcoal-saccharin method. MCCTs between ARIA,,classes were compared and correlations between TSS'or days with symptoms per week (DSW) and MCCT were analyzed. Results: Of the patients, 67.1% were moderate-severe degree. MSPAR had the worst MCCT, followed by MSIAR, MPAR, and MIAR(mean MCCTs of 14.32, 13.87, 11.94, and 10.28 minutes, respectively). TSS was well correlated with MCCT (P = .538, P < .001). DSW was also correlated with MCCT, but did not reach statistical significance (r = 0.217, P = .065). The mean MCCT of overall nasal symptoms increased along with each score step and a significant difference was noted between scores 2 and 3 (P < .001).Conclusions: A high percentage of moderate severe disease and a significant correlation of the severity and MCCTs suggest and important heterogeneity in this disease severity group. Discriminating between moderate and severe rhinitis should help to obtian homogeneous populations and develop improved disease management strategies.