Lung cancer rates convergence in young men and women in the United States: Analysis by birth cohort and histologic type
Lung cancer rates convergence in young men and women in the United States: Analysis by birth cohort and histologic type
复制标题
DOI：
10.1002/ijc.11020
复制
发表时间：
2003-05-20
影响因子：
6.4
通讯作者：
Devesa, SS
中科院分区：
文献类型：
--
作者：
Jemal, A;Travis, WD;Devesa, SS
在美国，男性的肺癌特异性发病率一直高于女性，主要是由于吸烟模式不同。然而，在最近的出生队列中，吸烟的性别差异已经缩小，特别是在白人中。我们使用了美国基于人口的发病率和死亡率数据，并根据性别、种族和组织学检查了出生队列的年龄特异性肺癌发病率趋势，以评估美国男性与女性肺癌风险的代际变化。所有统计学显著性检验均为双侧（95%置信区间[CI]）。肺癌死亡率在1960年以后出生的男性和女性之间趋于一致，特别是在白人中。在白人中，35-39岁男性与女性（M：F）的死亡率比从1915年出生队列的3.0（95% CI = 2.7-3.4）降至1960年出生队列的1.1（95% CI = 1.0-1.1），在黑人中，从1925年出生队列的4.0（95% CI = 3.2-5.0）降至1960年出生队列的1.5（95% CI = 1.3-1.7）。同样，白色男性和女性腺癌、小细胞癌和大细胞癌的发病率迅速收敛，但鳞状细胞癌的发病率较低。这些发现反映了白色和黑人男性和女性的吸烟模式：1960年以后出生的白色男性和女性在24岁时的吸烟率基本相同，但黑人男性的吸烟率继续高于女性。20世纪60年代以后出生的男性和女性肺癌死亡率的趋同支持了这样一种观点，即男性和女性可能同样容易因吸烟量而患肺癌，而不是女性更容易患肺癌的假设。(C)2003 Wiley-Liss，Inc.
Age-specific rates of lung cancer have been consistently higher for men than for women in the United States, due primarily to different patterns of cigarette smoking. Gender differences in cigarette smoking have diminished in recent birth cohorts, however, especially among whites. We used U.S. population-based incidence and mortality data and examined trends in age-specific rates of lung cancer by birth cohort according to gender, ethnic group, and histology to evaluate the generational changes in U.S. lung cancer risk for men vs. women. All tests of statistical significance are 2-sided (95% confidence interval [CI]). Lung cancer mortality rates have converged between men and women born after 1960, especially in whites. The male-to-female (M:F) mortality rate ratio for ages 35-39 years decreased from 3.0 (95% CI = 2.7-3.4) around the 1915 birth cohort to 1.1 (95% CI = 1.0-1.1) around the 1960 birth cohort among whites and from 4.0 (95% CI = 3.2-5.0) around the 1925 birth cohort to 1.5 (95% CI = 1.3-1.7) around the 1960 birth cohort among blacks. Similarly, incidence rates for white men and women converged rapidly for adenocarcinoma, small cell carcinoma, and large cell carcinoma, but less so for squamous cell carcinoma. These findings reflect the smoking patterns among white and black men and women: cigarette smoking prevalence at age 24 was essentially equal among white men and women born after 1960 but continued to be higher in black men than women. The convergence of lung cancer death rates among men and women born after 1960s supports the idea that males and females maybe equally susceptible to develop lung cancer from a given amount of cigarette smoking, rather than the hypothesis that women are more susceptible. (C) 2003 Wiley-Liss, Inc.