Salivary Sex Hormones during the Menstrual Cycle
Salivary Sex Hormones during the Menstrual Cycle
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DOI：
10.1507/endocrj.k09e-020
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发表时间：
2009-06-01
影响因子：
2
通讯作者：
Kudela, Matus
中科院分区：
文献类型：
--
作者：
Celec, Peter;Ostatnikova, Daniela;Kudela, Matus
女性性激素的昼夜节律在许多生理和病理生理过程中是重要的。由于采样问题，对这些节律的详细分析是困难的。当需要重复采样时，唾液中的性类固醇水平被广泛使用。然而，在月经周期期间的变化与每日采样的描述是缺乏的。在我们的研究中，测量了17名年轻健康女性（21.2 +/-0.7岁）在一个月经周期内每天收集的样本中的睾酮、雌二醇和孕酮的唾液水平。用放射免疫法测定性类固醇水平。在我们的研究中，唾液性类固醇的动力学类似于血浆中的已知动力学。雌二醇和睾酮的类似模式证实了女性睾酮作为雌二醇前体的假设。睾酮的初级（排卵期）峰和次级（黄体期）峰之后是雌二醇的类似峰。孕酮在黄体期达到最高浓度。这项研究表明，唾液中性类固醇水平的分析是信息丰富的，可用于神经内分泌，时间生物学和其他研究领域，当需要重复采样。
Infradian rhythms of sex hormones in women are important ill several physiological and pathophysiological processes. Detailed analyses of these rhythms are difficult due to problems with sampling. Salivary levels of sex steroids are widely used when repeated sampling is needed. However, a description of variation during the menstrual cycle with daily sampling is lacking. In Our study salivary levels of testosterone, estradiol and progesterone were measured in samples collected daily by 17 young healthy women (21,2 +/- 0,7 years) during one menstrual cycle. Sex steroid levels were determined using radioimmunoassay. The dynamics of salivary sex steroids in Our study resembles the known dynamics in plasma. Similar patterns for estradiol and testosterone confirm the hypothesis that in women testosterone serves as a precursor for estradiol. The primary (periovulatory) peak and secondary (luteal) peak of testosterone are followed by similar peaks of estradiol. Progesterone reaches maximum concentrations during the luteal phase. This study shows that analysis of salivary levels of sex steroids are informative and can be used in neuroendocrine, chronobiological and other research areas, when repeated sampling is needed.