Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer
Influence of tumor volume on survival in patients irradiated for non-small-cell lung cancer
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DOI：
10.1016/s0360-3016(02)02814-6
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发表时间：
2002-07-15
影响因子：
7
通讯作者：
Lind, PA
中科院分区：
文献类型：
--
作者：
Etiz, D;Marks, LB;Lind, PA
目的：探讨 CT 定义的总肿瘤体积 (TTV) 对无法切除或无法手术的非小细胞肺癌 (NSCLC) 患者总生存 (OS) 的重要性。 方法和材料：1991 年至 1998 年间，150 名可评估的 I-IIIB 期 NSCLC 患者在杜克大学医学中心接受了三维计划的适形放射治疗和治疗意图。在治疗计划 CT 上，确定了原发肿瘤和淋巴结体积，随后将其合并形成 TTV。使用 Kruskall-Wallis 方差分析和 Kaplan-Meier 精算方法将 TTV 与 OS、局部无进展生存期和远处无失败生存期等分期和结果进行比较。为了解释治疗和患者特异性协变量对生存的潜在混杂影响，使用了 Cox 比例风险回归模型。结果：I 期疾病患者（中位数 19 cm(3)）的 TTV 小于 II 期患者（中位数 80 cm(3)）或 III 期患者（中位数 97 cm(3)；p
Purpose: To investigate the importance of CT-defined total tumor volume (TTV) on overall survival (OS) in patients with unresectable or medically inoperable non-small-cell lung carcinoma (NSCLC).Methods and Materials: Between 1991 and 1998, 150 evaluable patients with Stage I-IIIB NSCLC were treated with three-dimensionally planned conformal radiotherapy and curative intent at Duke University Medical Center. On the treatment-planning CT, the primary tumor and nodal volumes were identified and subsequently combined to form the TTV. The TTV was compared with the stage and outcome with respect to OS, local progression-free survival, and distant failure-free survival using the Kruskall-Wallis analysis of variance and Kaplan-Meier actuarial method. To account for the potentially confounding effects of therapeutic and patient-specific covariates on survival, the Cox proportional hazard regression model was used.Results: The TTVs in patients with Stage I disease (median 19 cm(3)) were smaller than in patients with Stage II (median 80 cm(3)) or Stage III (median 97 cm(3); p