Adult Consequences of Extremely Preterm Birth Cardiovascular and Metabolic Diseases Risk Factors, Mechanisms, and Prevention Avenues
Adult Consequences of Extremely Preterm Birth Cardiovascular and Metabolic Diseases Risk Factors, Mechanisms, and Prevention Avenues
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DOI：
10.1016/j.clp.2017.01.010
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发表时间：
2017-06-01
影响因子：
2.1
通讯作者：
Luu, Thuy Mai
中科院分区：
文献类型：
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作者：
Nuyt, Anne Monique;Lavoie, Jean-Claude;Luu, Thuy Mai
极早产儿在发育的关键阶段会受到各种各样的伤害。极早产婴儿面临过早过渡到子宫外生理和经历适应机制，可能是有害的长期，因为永久性的器官结构和功能的改变。围产期事件也可直接引起结构损伤。这些紊乱会引起他们器官系统的形态和功能改变，可能会增加他们成年后患慢性疾病的风险。本文综述了早产后长期健康和疾病规划的病理生理学以及相关的围产期危险因素。
Extremely preterm babies are exposed to various sources of injury during critical stages of development. The extremely preterm infant faces premature transition to ex utero physiology and undergoes adaptive mechanisms that may be deleterious in the long term because of permanent alterations in organ structure and function. Perinatal events can also directly cause structural injury. These disturbances induce morphologic and functional changes in their organ systems that might heighten their risks for later adult chronic diseases. This review examines the pathophysiology of programming of long-term health and diseases after preterm birth and associated perinatal risk factors.