Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized wound care center
Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized wound care center
复制标题
DOI：
10.1111/j.1524-475x.2008.00438.x
复制
发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Koenigsrainer, Alfred
中科院分区：
文献类型：
--
作者：
Wicke, Corinna;Bachinger, Andreas;Koenigsrainer, Alfred
随着人口老龄化的急剧增加，老年人伤口的研究和护理已成为研究人员和临床医生的优先课题。衰老对人类伤口愈合的影响仍然存在争议。该研究是一项为期5年的流行病学评估，对患者在专门的伤口护理中心就诊期间定期收集的标准化数据进行评估，旨在确定影响慢性下肢伤口愈合的关键因素。在对1，158例慢性伤口的分析中，老年患者的伤口闭合频率在统计学上显著低于年轻患者。在老年患者（>= 70岁）中，闭合性伤口的比例下降了近25%。患者的年龄和伤口闭合比例之间的关系是非线性的。年龄对慢性伤口伤口闭合频率的影响在60岁后变得临床明显。伤口的慢性性通过其复发性、持续时间长、存在多处伤口和并发感染的频率来说明。合并症是通过与伤口愈合受损相关的最多三种基础疾病的共患病率来记录的。本研究清楚地表明，衰老对慢性伤口愈合有负面影响。
With the dramatic increase in the aging population, the study and care of wounds in the elderly have become priority topics for both researchers and clinicians. The effects of aging on wound healing in humans have remained controversial. The study was a 5-year epidemiological evaluation of standardized data collected regularly during patients' visits at a specialized Wound Care Center with the aim to determine the key factors influencing the healing of chronic lower extremity wounds. In this analysis of 1,158 chronic wounds, the frequency of wound closure was statistically significantly lower in older patients compared with younger patients. The share of closed wounds decreased by nearly 25% in the elderly patients (>= 70 years). The relationship between the patient's age and the proportion of wound closure was nonlinear. The effect of aging on the frequency of wound closure of chronic wounds became clinically apparent after age 60. The chronicity of the wounds was illustrated by their recurrent nature, their long duration, the presence of multiple wounds, and the frequency of concurrent infection. Comorbidity was documented by the coprevalence of up to three underlying diseases related to impaired wound healing. The present study clearly showed that aging affects chronic wound healing negatively.