Occurrence and congener specific profiles of polybrominated diphenyl ethers and their hydroxylated and methoxylated derivatives in breast milk from Catalonia
Occurrence and congener specific profiles of polybrominated diphenyl ethers and their hydroxylated and methoxylated derivatives in breast milk from Catalonia
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DOI：
10.1016/j.chemosphere.2008.09.050
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发表时间：
2009-01-01
期刊：
影响因子：
8.8
通讯作者：
Ikonomou, Michael G.
中科院分区：
文献类型：
--
作者：
Lacorte, Silvia;Ikonomou, Michael G.
从11位居住在巴塞罗那的母亲那里收集的37份母乳样本中检测了多溴联苯醚（PBDEs）的存在情况，包括单溴化到七溴化以及11种羟基化（OH-）和甲氧基化（MeO-）PBDEs。采用基于加速溶剂萃取和气相色谱-高分辨率质谱联用的萃取方法，在低pg g（-1）lw水平下明确鉴别所有目标化合物。对所获得的数据进行了检查，以确定其绝对和相对浓度以及特定的多溴二苯醚、羟基多溴二苯醚和甲氧基多溴二苯醚同系物模式。Sigma多溴二苯醚的浓度范围为1，161至1，372，797皮克/克（-1）脂重，溴二苯醚47、99、100、153和183占多溴二苯醚总量的80%以上。检测到的所有CH-和MeO-PBDEs三溴和四溴化合物的含量在6至14 984皮克/克（-1）脂重之间。Sigma OH/PBDE和MeO-PBDEs/PBDEs的中位比率分别为2.9%至1.6%，表明多溴二苯醚代谢为OH-和MeO-衍生物不是人体内的重要降解途径，或者OH-和MeO-PBDEs会迅速排出体外。尽管OH-和OMe-PBDE同时存在于母乳中，但PBDE与CH-和MeO-PBDE之间没有观察到显着相关性（R-2 = 0.5349）。根据多溴联苯醚和羟基多溴联苯醚及甲氧基多溴联苯醚的每日摄入量，即0.47至363纳克/天（不包括吸烟者），评估了与这些化合物有关的潜在健康风险。(C)2008爱思唯尔有限公司保留所有权利。
The presence of polybrominated diphenyl ethers (PBDEs) from mono to hepta brominated and 11 hydroxylated (OH-) and methoxylated (MeO-) PBDEs was examined in 37 breast milk samples collected from 11 mothers living in Barcelona. An extraction method based on accelerated solvent extraction followed by gas chromatography coupled to high resolution mass spectrometry was used to inequivocally identify all target compounds at the low pg g(-1) lw level. Data obtained were examined for absolute and relative concentrations and specific PBDE, OH- and MeO-PBDE congener patterns. Sigma PBDE concentration ranged between 1161 and 1372 797 pg g(-1) lw and BDEs 47, 99, 100, 153 and 183 accounted for more than 80% of the total PBDEs. All tri and tetra CH- and MeO-PBDEs compounds were detected at levels between 6 and 14 984 pg g(-1) lw. The median ratio Sigma OH/PBDE and MeO-PBDEs/PBDEs was from 2.9% to 1.6%, respectively, suggesting either that PBDE metabolism to OH- and MeO- derivatives is not an important degradation route in humans or either OH- and MeO-PBDEs are rapidly excreted. No significant correlation was observed between PBDEs and CH- and MeO-PBDE, although OH- and OMe-PBDEs co-occurred in mothers' milk (R-2 = 0.5349). According to the daily intake of PBDEs and OH- and MeO-PBDEs, which was between 0.47 and 363 ng d(-1) (excluding a smoking donor), potential health risks associated with these compounds are assessed. (C) 2008 Elsevier Ltd. All rights reserved.