Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons
Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons
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DOI：
10.1073/pnas.1613337113
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发表时间：
2016-10-04
影响因子：
11.1
通讯作者：
Graybiel, Ann M.
中科院分区：
文献类型：
--
作者：
Crittenden, Jill R.;Tillberg, Paul W.;Graybiel, Ann M.
大脑中的多巴胺系统对运动和动机有着强大的影响。我们证明，纹状体黑质纤维起源于纹状体形成非常不寻常的花束状树枝状，目标束腹侧延伸的含多巴胺的树突和集群的父母黑质细胞体。逆行追踪显示，这些成簇的细胞体又作为经典黑质纹状体通路的一部分投射到纹状体。因此，这些纹状体-树突形成，这里称为“纹状体-树突束”，可能代表具有黑质-纹状体-黑质环的子系统，其在包括帕金森病的人类疾病中受到影响。在花束中，扩展显微镜解析了许多个体的纹状体纤维与含多巴胺的树突紧密交织，并且还与由多巴胺能、GABA能和胆碱能标记物以及星形胶质细胞和纤维的标记物和连接蛋白43斑点标记的传入纤维紧密交织。我们认为，纹状体树突花束形成专门的整合单位内含有多巴胺的黑质系统。有证据表明，纹状体从与情绪和动机控制相关的皮质区域接收输入，并且它们在功能上与强化和决策相关，因此纹状体-树突花束可能对健康和疾病中的多巴胺相关功能至关重要。
The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed "striosome-dendron bouquets," likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease. Within the bouquets, expansion microscopy resolved many individual striosomal fibers tightly intertwined with the dopamine-containing dendrites and also with afferents labeled by glutamatergic, GABAergic, and cholinergic markers and markers for astrocytic cells and fibers and connexin 43 puncta. We suggest that the striosome-dendron bouquets form specialized integrative units within the dopamine-containing nigral system. Given evidence that striosomes receive input from cortical regions related to the control of mood and motivation and that they link functionally to reinforcement and decision-making, the striosome-dendron bouquets could be critical to dopamine-related function in health and disease.