The effect of cannabis laws on opioid use
The effect of cannabis laws on opioid use
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DOI：
10.1016/j.drugpo.2019.09.013
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发表时间：
2019-12-01
影响因子：
4.4
通讯作者：
D'Alessio, Stewart J.
中科院分区：
文献类型：
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作者：
Flexon, Jamie L.;Stolzenberg, Lisa;D'Alessio, Stewart J.
背景：许多美国人依赖不同剂量的阿片类药物来帮助减轻他们的痛苦。然而，越来越多的经验证据表明，阿片类药物在控制非癌症相关的慢性疼痛方面是无效的，许多人认为，旨在减轻患者痛苦的策略正在导致阿片类药物日益流行。同时，一些州现在允许使用医用大麻治疗各种疾病，包括慢性疼痛。大麻法律对一般阿片类药物依赖的影响，以及慢性疼痛患者是否选择使用大麻而不是阿片类药物，这些都需要更多的探索。方法：本研究利用美国国家药物使用与健康调查多年数据，采用多因素logistic回归和纵向分析策略，探讨医用大麻法（MML）对阿片类药物使用和滥用的影响。结果：结果提供的证据表明，MMLs可能有效减少对阿片类药物的依赖，因为生活在有医用大麻立法的州的调查对象报告使用阿片类镇痛药的可能性远远低于生活在没有此类法律的州的人，净其他因素。结果进一步表明，药用大麻立法的存在似乎对阿片类药物滥用没有影响。结论：mls可能最终有助于减轻阿片类药物过度依赖的后果。
Background: Many Americans rely on opioids at varying dosages to help ameliorate their suffering. However, empirical evidence is mounting that opioids are ineffective at controlling non-cancer related chronic pain, and many argue the strategies meant to relieve patient suffering are contributing to the growing opioid epidemic. Concurrently, several states now allow the use of medical cannabis to treat a variety of medical conditions, including chronic pain. Needing more exploration is the impact of cannabis laws on general opioid reliance and whether chronic pain sufferers are opting to use cannabis medicinally instead of opioids.Methods: This study investigates the effect of Medical Marijuana Laws (MML)s on opioid use and misuse controlling for a number of relevant factors using data from several years of the National Survey on Drug Use and Health and multivariate logistic regression and longitudinal analysis strategies.Results: Results provide evidence that MMLs may be effective at reducing opioid reliance as survey respondents living in states with medical cannabis legislation are much less apt to report using opioid analgesics than people living in states without such laws, net other factors. Results further indicate that the presence of medicinal cannabis legislation appears to have no influence over opioid misuse.Conclusion: MMLs may ultimately serve to attenuate the consequences of opioid overreliance.