Effects of ENU dosage on mouse strains
Effects of ENU dosage on mouse strains
复制标题
DOI：
10.1007/s003350010094
复制
发表时间：
2000-07-01
期刊：
影响因子：
2.5
通讯作者：
Bode, VC
中科院分区：
文献类型：
--
作者：
Justice, MJ;Carpenter, DA;Bode, VC
超诱变剂N-乙基-N-亚硝基脲（ENU）对小鼠具有多种作用。ENU是一种毒素和致癌物，也是一种诱变剂，各菌株对其影响的敏感性不同。因此，有必要确定用于实验的菌株的ENU的适当致突变、无毒剂量。为了提供一些指导，我们收集了一些实验室的数据，这些实验室将来自近交系和非近交系的雄性小鼠或其F-1杂种暴露于ENU。结果表明，大多数F-1杂交动物对ENU耐受良好，但近交系小鼠的寿命和用ENU治疗后恢复生育能力的能力各不相同。
The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F-1 hybrids to ENU. The results show that most F-1 hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.