Pain perception, obstructive imagery and phase-ordered gamma oscillations
Pain perception, obstructive imagery and phase-ordered gamma oscillations
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DOI：
10.1016/j.ijpsycho.2004.11.004
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发表时间：
2005-05-01
影响因子：
3
通讯作者：
Cacace, T
中科院分区：
文献类型：
--
作者：
De Pascalis, V;Cacace, T
心理意象的疼痛感知和抗伤害效应的神经机制还不清楚。最近，我们通过测量对疼痛电刺激的相序β和γ EEG振荡，发现由Cz头皮部位疼痛刺激引起的体感事件相关相序γ振荡（38-42 Hz）与疼痛感知呈线性相关。在本研究中，38名受试者进行了一个痛苦的刺激检测任务，使用一个古怪的范式。这项任务进行的条件下，受试者被要求简单地计算目标刺激的数量（疼痛条件），并在另一个条件下，受试者被要求产生一个阻碍性的心理意象的痛苦刺激的知觉（阻碍性意象）。本研究仅分析了对标准刺激的EEG反应。对每个人扫描的相关性分析显示，在β和γ波段，EEG模式的相位顺序有短暂的间隔。感兴趣的频率是β 1（26-30 Hz）、β 2（30-34 Hz）、γ 1（3438 Hz）、γ 2（38-42 Hz）和γ 3（42-46 Hz）频带。阻碍性想象治疗，与疼痛状况相比，疼痛感知显著降低。这种减少被Cz头皮部位诱发的相序γ 2和γ 3模式的显著减少所掩盖。相序振荡在Cz头皮网站，为γ 2和γ 3波段，显着预测疼痛状态下的疼痛评级。相序振荡分数，获得这些伽玛波段在顶叶和额叶头皮网站，导致最好的预测疼痛评级在阻塞性成像。这项研究提供了证据的作用，伽玛振荡的主观经验的疼痛。此外，它提供了支持的观点，即疼痛的减少，在阻塞性心理意象是一个抑制过程的产物，涉及额叶和顶叶皮层区域。(c)2005 Elsevier B. V.保留所有权利。
The neural mechanisms underlying pain perception and anti-nociceptive effects of mental imagery are not well understood. Using a measure of phase-ordered beta and gamma EEG oscillations in response to painful electric stimulation, we recently found that somatosensory event-related phase-ordered gamma oscillations (38-42 Hz), elicited by the onset of painful stimuli over Cz scalp site, were linearly related to pain perception. In the present study, 38 subjects were engaged in a painful stimulus detection task using an oddball paradigm. This task was performed under a condition in which subjects were required simply to count the number of target stimuli (pain condition) and under another condition in which subjects were required to produce an obstructive mental imagery of painful stimulus perception (obstructive imagery). Only EEG responses to standard stimuli were analyzed in this study. Correlation analysis of sweeps for each individual revealed brief intervals of phase ordering of EEG patterns in the beta and gamma bands. The frequencies of interest were the betal (26-30 Hz), beta2 (30-34 Hz), gammal (3438 Hz), gamma2 (38-42 Hz) and gamma3 (42-46 Hz) bands. Obstructive imagery treatment., compared to pain condition, significantly reduced pain perception. This reduction was paralleled by significant decreases of evoked phase-ordered gamma2 and gamma3 patterns over Cz scalp site. Phase-ordered oscillations at Cz scalp site, for both gamma2 and gamma3 bands, significantly predicted pain ratings during pain condition. Phase-ordered oscillation scores, obtained for these gamma bands over parietal and frontal scalp sites, resulted the best predictor of pain ratings during obstructive imagery. This study provides evidence for the role of gamma oscillations in the subjective experience of pain. Further, it has provided support for the view that pain reduction during obstructive mental imagery is the product of an inhibitory process involving frontal and parietal cortical regions. (c) 2005 Elsevier B.V. All rights reserved.