Trends in Antihypertensive Medication Use Among US Patients With Resistant Hypertension, 2008 to 2014
Trends in Antihypertensive Medication Use Among US Patients With Resistant Hypertension, 2008 to 2014
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DOI：
10.1161/hypertensionaha.116.08128
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发表时间：
2016-12-01
期刊：
影响因子：
8.3
通讯作者：
Smith, Steven M.
中科院分区：
文献类型：
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作者：
Hwang, Andrew Y.;Dave, Chintan;Smith, Steven M.
对于难治性高血压（TRH）患者在美国使用降压药的趋势知之甚少。我们使用Marketscan管理数据分析了2008年7月至2014年12月TRH患者（同时使用4种降压药物治疗）的降压使用情况。我们纳入了年龄在18至65岁之间的成年人，连续入组6个月，有高血压诊断，1次重叠使用4种抗高血压药物；排除心力衰竭患者。我们从261652例平均年龄55.9岁的患者中确定了411652例独特的TRH发作。从2008年到2014年，我们观察到在TRH发作中-阻滞剂（+6.8%[79%至85.8%]）和二氢吡啶钙拮抗剂（+8.1%[69.1%至77.2%]）的患病率增加，血管紧张素转换酶抑制剂（-12.5%[60.4%至47.9%]）和非二氢吡啶钙拮抗剂（-5.0%[15%至10%]）的患病率下降。其他阶级的盛行率大多由
Little is known of US trends in antihypertensive drug use for patients with treatment-resistant hypertension (TRH). We analyzed antihypertensive use among patients with TRH (treated with 4 antihypertensive drugs concurrently) from July 2008 through December 2014 using Marketscan administrative data. We included adults aged 18 to 65 years, with 6 months of continuous enrollment, a hypertension diagnosis, and 1 episode of overlapping use of 4 antihypertensive drugs; patients with heart failure were excluded. We identified 411652 unique TRH episodes from 261652 patients with a mean age of 55.9 years. From 2008 to 2014, we observed an increased prevalence, among TRH episodes, of -blockers (+6.8% [79% to 85.8%]) and dihydropyridine calcium antagonists (+8.1% [69.1% to 77.2%]), and a decreased prevalence of angiotensin-converting enzyme inhibitors (-12.5% [60.4% to 47.9%]) and nondihydropyridine calcium antagonists (-5.0% [15% to 10%]). The prevalence of most other classes changed by