Catalytic enantioselective borohydride reduction of ortho-fluorinated benzophenones
Catalytic enantioselective borohydride reduction of ortho-fluorinated benzophenones
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DOI：
10.1021/ol060927p
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发表时间：
2006-07-06
期刊：
影响因子：
5.2
通讯作者：
Yamada, Tohru
中科院分区：
文献类型：
--
作者：
Kokura, Ai;Tanaka, Saiko;Yamada, Tohru
[GRAPHICS]In the presence of the optically active ketoiminatocobalt(II) complexes, the enantioselective borohydride reduction of benzophenones was successfully completed. The fluorine atom on the ortho position of the benzophenone and aryl ketones proved effective for obtaining high enantioselectivities. The combined use of modified lithium borohydride afforded the corresponding benzhydrols and arylcarbinols in high yield and high enantioselectivity (88-96% ee).
