INFLUENCE OF THE GLOBUS PALLIDUS ON ARM MOVEMENTS IN MONKEYS .3. TIMING OF MOVEMENT-RELATED INFORMATION
INFLUENCE OF THE GLOBUS PALLIDUS ON ARM MOVEMENTS IN MONKEYS .3. TIMING OF MOVEMENT-RELATED INFORMATION
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DOI：
10.1152/jn.1985.54.2.433
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
HORAK, FB
中科院分区：
文献类型：
--
作者：
ANDERSON, ME;HORAK, FB
训练猴子在一个简单的反应时间范式中，对一个点亮的按钮进行视觉触发的手臂伸展运动，在此过程中测量反应时间(RT)和移动时间(MT)。在苍白球运动前和运动过程中的不同时间给予不同持续时间的刺激列车，在施加长刺激列车导致MT增加的位置。确定了一个关键的刺激期，在此期间施加刺激有效地延长了MT。在执行相同的行为任务时，检测苍白球神经元的活动。在被检查的神经元中，60%的神经元在到达运动之前或期间开始出现与任务相关的活动变化。对于这些细胞中的45%，最初的放电变化发生在关键的刺激期，即机械检测到运动之前50-150ms。比较关键刺激期、苍白球神经元放电的任务相关变化时间和背部、肩部、肘部和手腕肌肉的肌电活动时间，发现关键刺激期和神经元放电的变化都发生在肌肉最初激活或激活之后和肌电活动增强的过程中。显然，苍白球在决定运动速度的肌肉活动的大小方面发挥了作用，而不影响程序化运动输出的启动或顺序组织。
Monkeys were trained to make a visually triggered arm-reaching movement to a lighted button in a simple reaction-time paradigm, during which the reaction time (RT) and movement time (MT) were measured. Stimulus trains of varying duration were applied at various times before and during the movement at locations in the globus pallidus where application of long stimulus trains caused increased MT. a critical stimulus period was identified during which stimulus application effectively prolonged MT. The activity of pallidal neurons was examined during performance of the same behavioral task. Of the neurons examined > 60% showed task-related changes in activity that began before or during the reaching movement. For 45% of these cells, the initial change in firing occurred during the critical stimulus period, 50-150 ms before mechanically detected movement. Comparison of the critical stimulus period the time of task-related changes in the discharge of pallidal neurons, and the time of EMG [electromyographic] activity in muscles acting at the back, shoulder, elbow and wrist revealed that both the critical stimulus period and changes in neuronal discharge occurred at or after initial muscle activation and during the buildup of EMG activity. The globus pallidus evidently plays a role in scaling the magnitude of muscle activity that determines movement velocity without affecting the initiation or sequential organization of the programmed motor output.