Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.
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DOI：
10.3389/fnmol.2015.00068
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发表时间：
2015
影响因子：
4.8
通讯作者：
Kranz TM
中科院分区：
文献类型：
--
作者：
Daskalakis NP;De Kloet ER;Yehuda R;Malaspina D;Kranz TM
早期生活压力（ELS）与多种精神疾病的病因有关。ELS的重要生物学效应表现在海马的应激敏感区域，并且部分通过对糖皮质激素（GC）和/或神经营养因子信号通路的长期作用介导。GC-信号传导介导应激反应的调节以维持稳态，而神经营养因子信号传导在神经元生长中起关键作用，并且对于轴突引导和突触完整性至关重要。神经营养因子和GC信号通路在整个中枢神经系统（CNS）中共存，特别是在海马中，其具有糖皮质激素受体（GR）和盐皮质激素受体（MR）以及脑源性神经营养因子（BDNF）及其受体原肌球蛋白相关激酶受体B（Trk B）的高表达水平。本文综述了ELS范式对GC和BDNF依赖性机制及其在海马中的串扰的影响，包括对常见应激相关疾病发病机制的潜在影响。
Early life stress (ELS) is implicated in the etiology of multiple psychiatric disorders. Important biological effects of ELS are manifested in stress-susceptible regions of the hippocampus and are partially mediated by long-term effects on glucocorticoid (GC) and/or neurotrophin signaling pathways. GC-signaling mediates the regulation of stress response to maintain homeostasis, while neurotrophin signaling plays a key role in neuronal outgrowth and is crucial for axonal guidance and synaptic integrity. The neurotrophin and GC-signaling pathways co-exist throughout the central nervous system (CNS), particularly in the hippocampus, which has high expression levels of glucocorticoid-receptors (GR) and mineralocorticoid-receptors (MR) as well as brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB). This review addresses the effects of ELS paradigms on GC- and BDNF-dependent mechanisms and their crosstalk in the hippocampus, including potential implications for the pathogenesis of common stress-related disorders.