A spectroscopic and molecular modeling of sinomenine binding to transferrin

A spectroscopic and molecular modeling of sinomenine binding to transferrin
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DOI:
10.1016/j.bmcl.2006.12.069
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发表时间:
2007-03-15
影响因子:
2.7
通讯作者:
Tang, Yalin
Tang, Yalin
中科院分区:
医学4区
文献类型:
--
作者:
Du, Hongyan;Xiang, Junfeng;Tang, Yalin

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Sinomenine, an herbal ingredient isolated from Sinomenium acutum, is used for the amelioration of arthritis. It has been found that this molecule could bind to human serum transferrin (Tf), the iron (III) transport protein in the blood, by using fluorescence, circular dichroism (CD) spectroscopy, and molecular modeling methods. The results provide possible usage of transferrin to transport sinomenine. (c) 2006 Elsevier Ltd. All rights reserved.