Rapid effects of the G-protein coupled oestrogen receptor (GPER) on learning and dorsal hippocampus dendritic spines in female mice
Rapid effects of the G-protein coupled oestrogen receptor (GPER) on learning and dorsal hippocampus dendritic spines in female mice
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DOI：
10.1016/j.physbeh.2015.05.017
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发表时间：
2015-10-01
影响因子：
2.9
通讯作者：
Choleris, Elena
中科院分区：
文献类型：
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作者：
Gabor, Christopher;Lymer, Jennifer;Choleris, Elena
最近，雌激素受体(ER)被认为与快速学习过程有关。我们之前已经证明，17种β-雌二醇、ERα和ERβ激动剂可以在给药后40分钟内改善小鼠的学习能力。然而，雌激素对经典感受器的作用可能只能部分解释这些快速学习效应。一种G蛋白偶联雌激素受体(GPER)激动剂的慢性治疗已被证明影响去卵巢大鼠的学习和记忆，但对其快速学习效果知之甚少。因此，我们研究了GPER激动剂G-1在给药40min内对去卵巢CD1小鼠的社会再认、物体再认和物体放置学习的影响。我们还检测了G-1在给药后40分钟内对CA1区树突棘密度和长度的快速影响，但在没有任何学习测试的情况下。结果表明，GPER激活对社会再认、物体再认和物体放置学习有显著的促进作用。G-1处理还导致CA1海马区放射层中树突棘密度增加。因此，GPER与经典的ERs一起，可能介导雌激素对学习和神经元可塑性的快速影响。据我们所知，这是40分钟内发生的GPER效应的第一份报告。(C)2015 Elsevier Inc.保留所有权利。
Recently, oestrogen receptors (ERs) have been implicated in rapid learning processes. We have previously shown that 17 beta-estradiol, ER alpha and ER beta agonists can improve learning within 40 min of drug administration in mice. However, oestrogen action at the classical receptors may only in part explain these rapid learning effects. Chronic treatment of a G-protein coupled oestrogen receptor (GPER) agonist has been shown to affect learning and memory in ovariectomized rats, yet little is known about its rapid learning effects. Therefore we investigated whether the GPER agonist G-1 at 1 mu g/kg, 6 mu g/kg, 10 mu g/kg, and 30 mu g/kg could affect social recognition, object recognition, and object placement learning in ovariectomized CD1 mice within 40 min of drug administration. We also examined rapid effects of G-1 on CA1 hippocampal dendritic spine density and length within 40 min of drug administration, but in the absence of any learning tests. Results suggest a rapid enhancing effect of GPER activation on social recognition, object recognition and object placement learning. G-1 treatment also resulted in increased dendritic spine density in the stratum radiatum of the CA1 hippocampus. Hence GPER, along with the classical ERs, may mediate the rapid effects of oestrogen on learning and neuronal plasticity. To our knowledge, this is the first report of GPER effects occurring within a 40 min time frame. (C) 2015 Elsevier Inc. All rights reserved.