THE PARTICIPATION OF HEAVY METAL IONS IN THE HYDROLYSIS OF AMINO ACID ESTERS
THE PARTICIPATION OF HEAVY METAL IONS IN THE HYDROLYSIS OF AMINO ACID ESTERS
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DOI：
10.1021/ja01128a051
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发表时间：
1952-01-01
影响因子：
15
通讯作者：
KROLL, H
中科院分区：
文献类型：
--
作者：
KROLL, H
研究了重金属二价离子存在下氨基酸酯的水解速率。一种机制是假设，其中涉及的氨基酸酯和氢氧根离子的金属络合物之间的二级反应。水解速率取决于α氨基酸酯侧链的性质和金属离子的络合倾向。在我们对金属离子在生物系统中的作用的研究中，4观察到重金属离子在pH 7.5-8.5的范围内加速氨基酸酯的水解。为了获得有助于理解金属离子活化酶催化水解反应本质的信息，对该反应进行了更深入的研究。5
The rates of hydrolysis of-amino acid esters in the presence of heavy metal divalent ions were investigated. A mechanism is postulated which involves a second-order reaction between a metal complex of the amino acidester and hydroxyl ions. The hydrolytic rate is determined by the nature of the side chain in the alpha amino acid ester and the complexing tendency of the metal ion.In a continuation of our studies on the effects of metal ions in biological systems, 4 it was observed that heavy metal ions accelerated the hydrolysis of amino acid esters in the pH range of 7.5-8.5. This reaction was investigated more closely in order to obtain information which could contribute to an understanding of the nature ofmetal ion activation of enzyme catalyzed hydrolytic re-actions. 5