Osteoarthritis susceptibility loci defined by genome scan meta-analysis
Osteoarthritis susceptibility loci defined by genome scan meta-analysis
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DOI：
10.1007/s00296-006-0120-9
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发表时间：
2006-09-01
影响因子：
4
通讯作者：
Song, Gwan Gyu
中科院分区：
文献类型：
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作者：
Lee, Young Ho;Rho, Young Hee;Song, Gwan Gyu
骨关节炎（OA）的基因组扫描产生了不一致的结果。缺乏关联的复制可能是由于缺乏个体研究的力量。对已发表的数据进行荟萃分析，以评估OA在基因组扫描研究中的关联证据。三次OA全基因组扫描，包括893个家庭和3000名受影响的个体，用于基因组扫描荟萃分析（GSMA）。OA GSMA中有5个箱子位于95%置信水平以上（P=0.05）， 1个箱子位于99%置信水平以上（P=0.01）；本例为7.6 （7q34-7q36.3, P (sumrnk) =0.0035）、11.3 （11p12-11q13.4）、6.3 （6p21.1-6q15）、2.8 （2q31.1-2q34）、15.3 （15q21.3-15q26.1）。总数最高的垃圾箱为7.6个垃圾箱。综上所述，OA GSMA显示染色体7q34-7q36.3具有最高的求和秩，另外4个位点在研究中具有显著的求和秩。
Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P (sumrnk) =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.