Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patients.
Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV positive patients.
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DOI：
10.1186/1743-422x-6-202
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发表时间：
2009-11-18
期刊：
影响因子：
4.8
通讯作者：
Boroun H
中科院分区：
文献类型：
--
作者：
Mohammadi M;Talei G;Sheikhian A;Ebrahimzade F;Pournia Y;Ghasemi E;Boroun H
HIV、HBV 和 HCV 是主要的公共卫生问题。由于共有传播途径，HIV-HCV 合并感染和 HIV-HBV 合并感染很常见。 HIV 阳性个体存在同时感染 HBV 和 HCV 感染的风险。全球艾滋病毒患者中乙型肝炎病毒和丙型肝炎病毒合并感染的患病率因地理区域和暴露类型而异。本研究旨在从血清学角度检查 HBV 和 HCV 合并感染，并确定 HIV 阳性患者合并感染的共同且重要的因素。这项描述性横断面研究针对伊朗西部洛雷斯坦省的 391 名 HIV 阳性患者（包括 358 名男性和 33 名女性）进行，旨在调查 HBsAg 和抗 HCV 的双重感染。收集受试者的回顾性人口统计数据，并通过包括 HBsAg 和抗 HCV 在内的 ELISA 试剂盒对患者血清进行分析。使用 SPSS 软件 (15) 和卡方分析收集的数据。采用 5% 误差区间的 Fisher 精确检验来衡量变量与感染率的相关性。研究结果表明，HIV阳性患者中肝炎病毒合并感染率为94.4%（391例中有370例），其中HBsAg阳性57例（14.5%），抗HCV阳性282例（72%），HBsAg和抗HCV同时阳性31例（7.9%）。 HIV 阳性患者中 HCV 和 HBV 和/或两者同时感染之间存在显着相关性，具体取决于性别、年龄、职业、婚姻状况、危险因素暴露等不同变量。(p < 0.001)。
HIV, HBVand HCV is major public health concerns. Because of shared routes of transmission, HIV-HCV coinfection and HIV-HBV coinfection are common. HIV-positive individuals are at risk of coinfection with HBV and HCV infections. The prevalence rates of coinfection with HBV and HCV in HIV-patients have been variable worldwide depending on the geographic regions, and the type of exposure. This study aimed to examine HBV and HCV coinfection serologically and determine the shared and significant factors in the coinfection of HIV-positive patients. This descriptive, cross-sectional study was carried out on 391 HIV-positive patients including 358 males and 33 females in Lorestan province, west Iran, to survey coinfection with HBsAg and anti-HCV. The retrospective demographic data of the subjects was collected and the patients' serums were analyzed by ELISA kits including HBsAg and anti-HCV. The collected data was analyzed with SPSS software (15) and Chi-square. Fisher's exact test with 5% error intervals was used to measure the correlation of variables and infection rates. The results of the study indicated that the prevalence of coinfection in HIV-positive patients with hepatitis viruses was 94.4% (370 in 391), out of whom 57 (14.5%) cases were HBsAg positive, 282 (72%) cases were anti-HCV positive, and 31 (7.9%) cases were both HBsAg and anti-HCV positive. There was a significant correlation between coinfection with HCV and HBV and/or both among HIV-positive patients depending on different variables including sex, age, occupation, marital status, exposure to risk factors.(p < 0.001).