Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia.
Cdx genes, inflammation, and the pathogenesis of intestinal metaplasia.
复制标题
Cdx基因、炎症与肠化生的发病机制
DOI：
10.1016/b978-0-12-381280-3.00010-5
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发表时间：
2010
影响因子：
--
通讯作者：
Lynch JP
中科院分区：
文献类型：
--
作者：
Stairs DB;Kong J;Lynch JP
Intestinal metaplasia is a biologically interesting and clinically relevant condition in which one differentiated type of epithelium is replaced by another that is morphologically similar to normal intestinal epithelium. Two classic examples of this are gastric intestinal metaplasia and Barrett’s esophagus. In both, a chronic inflammatory microenvironment, provoked either by Helicobacter pylori infection of the stomach or acid and bile reflux into the esophagus, precedes the metaplasia. The Caudal-related homeodomain transcription factors Cdx1 and Cdx2 are critical regulators of the normal intetinal epithelial cell phenotype. Ectopic expression of Cdx1 and Cdx2 occurs in both gastric intestinal metaplasia as well as in Barrett’s esophagus. This expression precedes the onset of the metaplasia and implies a causal role for these factors in this process. We will review the observations regarding the role of chronic inflammation and the Cdx transcription factors in the pathogenesis of gastric intestinal metaplasia and Barrett’s esophagus.
