An Objective Evaluation of Gaze Tracking in Humphrey Perimetry and the Relation With the Reproducibility of Visual Fields: A Pilot Study in Glaucoma
An Objective Evaluation of Gaze Tracking in Humphrey Perimetry and the Relation With the Reproducibility of Visual Fields: A Pilot Study in Glaucoma
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DOI：
10.1167/iovs.14-15541
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发表时间：
2014-12-01
影响因子：
4.4
通讯作者：
Asaoka, Ryo
中科院分区：
文献类型：
--
作者：
Ishiyama, Yukako;Murata, Hiroshi;Asaoka, Ryo
目的.发展一种新的方法来评估视线追踪（GT）的结果，并研究它们与视野（VF）测量的重测重复性的关系。受试者包括42名青光眼患者的42只眼。在使用Humphrey视野分析仪进行VF测试期间，使用VF测试仪底部的注视注视折线图评价视觉注视。我们定义了一些GT参数如下：每个刺激的平均跟踪失败频率（TFF），1度和2度之间，3度和5度之间，以及超过6度的眼球运动的平均频率。Humphrey VF（24-2和10-2瑞典交互阈值算法[SITA]标准）在3个月内对42例青光眼患者进行了两次前瞻性检查。测量了测试-重测VF中总偏差（TD）值的平均绝对变异性，并使用线性模型校正的Akaike信息标准（AICc）研究了其与注视损失（FL）、假阳性（FP）、假阴性（FN）、平均偏差（MD）和模式标准偏差（PSD）的关系。预测24-2 VF重测变异性的最佳模型包括PSD、TFF和FN作为因变量，而预测10-2 VF重测变异性的最佳模型包括PSD和3度和5度之间眼动的平均频率（所有系数均P <0. 05）。注视跟踪参数与VF结果的可重复性密切相关，在评估VF测试的可靠性时，客观地使用这些参数将是有益的。
PURPOSE. To develop a novel method to evaluate gaze tracking (GT) results and to examine their relationship with test-retest reproducibility of visual field (VF) measurements.METHODS. Subjects comprised of 42 eyes of 42 glaucoma patients. Vision fixation during VF tests with the Humphrey Field Analyzer was evaluated using the gaze fixation line chart at the bottom of the VF printout. We defined some GT parameters as follows: average tracking failure frequency per stimulus (TFF), average frequency of eye movements between 1 degrees and 2 degrees, 3 degrees and 5 degrees, and more than 6 degrees. Humphrey VFs (24-2 and 10-2 Swedish Interactive Threshold Algorithm [SITA] standard) were prospectively examined twice within a period of 3 months in 42 glaucoma patients. Mean absolute variability of total deviation (TD) values in the test-retest VFs was measured and its relationship to fixation losses (FLs), false positives (FPs), false negatives (FNs), mean deviation (MD), and pattern standard deviation (PSD) was investigated using the corrected Akaike Information Criterion (AICc) from linear modeling.RESULTS. The best model to predict test-retest variability in the 24-2 VF included PSD, TFF, and FNs as dependent variables, while the best model for the 10-2 VF included PSD and average frequency of eye movements between 3 degrees and 5 degrees (P < 0.05 for all coefficients).CONCLUSIONS. Gaze tracking parameters are closely related to the reproducibility of VF results, and it would be beneficial to objectively use these parameters when estimating the reliability of VF tests.