Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study
Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study
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DOI：
10.1016/j.joca.2007.12.010
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发表时间：
2008-09-01
影响因子：
7
通讯作者：
Kraus, V. B.
中科院分区：
文献类型：
--
作者：
Chen, H. -C.;Shah, S.;Kraus, V. B.
目的：评估生物标志物作为临床骨关节炎（OA）在一个大的多代家庭中的carriinas的美国被称为CARRIAGE（卡罗莱纳州地区相互作用的老化，基因和环境）family.Methods的潜在数量性状：在一系列的三个家庭团聚超过6年，我们确定了365个家庭成员。我们进行了临床手部检查（n = 287），并获得了七种OA相关生物标志物的血清（n = 278）[IIA型胶原N-前肽（PIIANP），II型前胶原羧基前肽（CPII），CII裂解的新表位（C2C），软骨寡聚基质蛋白（COMP），透明质酸（HA），高敏C反应蛋白（hs-CRP）和糖化血清蛋白（GSP）]。评估了三种手OA定义-临床ACR（美国风湿病学会）和GOGO（全身性OA遗传学）标准，以及任何单手关节受累。非手OA被定义为CA的阴性手检查，但不同的关节症状的患病率;对照组被定义为既没有症状，也没有临床手OA的证据。结果：平均在HA，在COMP，在hs-CRP显着高于手OA组，与非手OA或对照组。校正年龄和性别后，手OA组的平均In PIIANP（胶原蛋白11合成标记物）显著低于其他组。在那些没有临床手CA，GSP与手关节symptoms.Conclusions：这是第一份报告，据我们所知，显示了OA生物标志物和手OA的基础上单独体检的关联。使用这些生物标志物作为数量性状的分析可以揭示新的遗传位点，并促进对OA遗传易感性的探索。(C)2008年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To evaluate biological markers as potential quantitative traits of clinical osteoarthritis (OA) in a large multigenerational family in the Carolinas of the USA known as the CARRIAGE (CARolinas Region Interaction of Aging, Genes and Environment) family.Methods: During a series of three family reunions over 6 years, we ascertained 365 family members. We performed clinical hand examinations (n = 287), and obtained sera (n = 278) for seven OA-related bomarkers [type IIA collagen N-propeptide (PIIANP), type II procollagen carboxypropeptide (CPII), neoepitope from cleavage of CII (C2C), cartilage oligomeric matrix protein (COMP), hyaluronan (HA), high-sensitive C-reactive protein (hs-CRP), and glycated serum protein (GSP)]. Three hand OA definitions were evaluated - clinical ACR (American College of Rheumatology) and GOGO (Genetics of Generalized OA) criteria, and any single hand joint involvement. Non-hand OA was defined as a negative hand examination for CA but varying prevalence of joint symptoms; the control group was defined as having neither symptoms nor evidence for clinical hand OA.Results: Mean In HA, In COMP, and In hs-CRP were significantly higher in the hand OA group, compared with the non-hand OA or control group. Adjusted for age and sex, mean In PIIANP (a collagen 11 synthesis marker) was significantly lower in the hand OA group compared with the other groups. Among those without clinical hand CA, GSP was associated with hand joint symptoms.Conclusions: This is the first report, to our knowledge, showing an association of OA biomarkers and hand OA based on physical examination alone. Analyses using these biomarkers as quantitative traits could reveal novel genetic loci and facilitate exploration of the genetic susceptibility to OA. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.