Psychosocial Hypertension in Members of a Wistar Rat Colony 1
Psychosocial Hypertension in Members of a Wistar Rat Colony 1
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Wistar 大鼠群体 1 成员的心理社会高血压
DOI：
10.3181/00379727-146-38063
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发表时间：
1974
影响因子：
--
通讯作者：
N. Alexander
中科院分区：
文献类型：
--
作者：
N. Alexander
本研究旨在通过聚合引起的持续社会心理刺激诱导大鼠高血压。从断奶到4-5月龄均分离雌雄Wistar大鼠。在隔离的最后2个月和聚集的8周内，每隔一周测量一次尾袖压力。在两种物理条件下进行聚集：(1)6个相互连接的笼子，在中央饮食区周围形成轮状排列；(2)单笼。采用两轮，每轮24只，雌雄各12只，单笼10只，每笼2只或4只雌雄同体。其他雌雄老鼠被隔离作为对照。在所有聚集的大鼠中，大约有三分之一的雌雄大鼠在聚集期间表现出15毫米汞柱或更高的收缩压平均升高；其他聚集大鼠的平均压力上升幅度较小。单笼的大鼠不打架，轮聚集的雌性也不打架；然而，这些大鼠的动脉压升高。在发生高血压的轮聚集雄性中，那些被尾巴咬伤次数最少的优势类型的压力增加最大。优势雄轮与非优势雄轮的压力增加频率相同。
Summary This study was an attempt to induce hypertension in rats by the continuous psychosocial stimuli caused by aggregation. Wistar rats of both sexes were isolated from weaning to 4-5 mo of age. Tail cuff pressures were obtained every other week during the last 2 mo of isolation and up to 8 weeks of aggregation. Two types of physical conditions were used for aggregation: (1) 6 interconnecting cages in a wheel-like arrangement around a central eating and drinking area; (2) a single cage. Two wheels were used each with 24 rats, 12 males and 12 females and 10 single cages, each with 2 or 4 rats of the same sex. Other rats of both sexes remained isolated as controls. Approximately one-third of all aggregated rats of both sexes showed a 15 mm Hg or more average increase of systolic pressure during aggregation; other aggregated rats showed less average pressure rise. Rats in single cages did not fight nor did wheel aggregated females; nevertheless, arterial pressure increased among these rats. Among wheel aggregated males that developed hypertension, those classified as dominant types, by the least number of tail bites, had the largest pressure increases. The frequency of pressure increase was the same in dominant and nondominant wheel males.