Neuroendocrine peptide receptors on cells of the immune system.
Neuroendocrine peptide receptors on cells of the immune system.
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DOI：
10.1159/000058656
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发表时间：
1992-07
影响因子：
--
通讯作者：
H. Garza;D. Carr
中科院分区：
文献类型：
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作者：
H. Garza;D. Carr
神经肽受体在免疫系统中的功能作用似乎是感觉和调节。由免疫或神经内分泌细胞分泌的信号分子（即神经肽/神经递质）可以与免疫细胞膜结合的神经内分泌肽受体特异性相互作用，导致免疫稳态的变化。在本综述开始时，建立了三个标准，以正式定义受体的存在，包括药理学，生物化学和生物学特征。应用这些标准，至少有10种神经内分泌肽/肽神经递质受体符合要求（表1）。也许更引人注目的是，这些受体中的许多具有与神经内分泌组织上发现的那些受体几乎相同的特征。这一观察结果表明，一个组织隔室（神经内分泌或免疫）中受体系统的生理学不规则性也可能反映在另一个隔室（神经内分泌或免疫）中发现的受体上。事实上，这一假设性的概念得到了研究免疫细胞上ACTH、CRH和TRH受体相对于神经内分泌组织中这些受体的表达或功能的数据的支持，这些受体取自神经内分泌疾病患者。未来的工作可能会利用这种关系来进一步研究免疫和神经内分泌系统之间的动态相互作用，以定义神经系统，神经内分泌和自身免疫性疾病。
The functional role of neuropeptide receptors in the immune system seems to be sensory and regulatory. Signaling molecules (i.e. neuropeptides/neurotransmitters) secreted by immune or neuroendocrine cells can interact with specificity to immunocyte membrane bound neuroendocrine peptide receptors resulting in changes in immune homeostasis. At the onset of this review, three criteria were established in order to formally define the existence of a receptor including the pharmacologic, biochemical, and biological profiles. Applying these criteria, at least ten neuroendocrine peptide/peptide neurotransmitter receptors have met the requirements (table 1). Perhaps more striking, many of these receptors have characteristics which are nearly identical to those receptors found on neuroendocrine tissue. This observation implies irregularities in the physiology of a receptor system in one tissue compartment (neuroendocrine or immune) may be mirrored by the receptors found in the other compartment (neuroendocrine or immune) as well. This rather hypothetical concept is, in fact, supported by data studying ACTH, CRH, and TRH receptors on immune cells relative to the expression or function of these receptors in neuroendocrine tissue taken from patients with neuroendocrine disorders. It is likely that future work will use this relationship to further study the dynamic interaction between the immune and neuroendocrine systems in defining neurologic, neuroendocrine, and autoimmune disorders.