Intrinsic and Innate Defenses of Neurons: Detente with the Herpesviruses
Intrinsic and Innate Defenses of Neurons: Detente with the Herpesviruses
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DOI：
10.1128/jvi.01200-16
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发表时间：
2017-01-01
影响因子：
5.4
通讯作者：
Leib, David A.
中科院分区：
文献类型：
--
作者：
Enquist, Lynn W.;Leib, David A.
神经侵袭性疱疹病毒已经进化到可以有效地感染并在神经元中建立潜伏期。神经系统的再生能力有限，因此其中的免疫反应被精心调节为非破坏性的，依赖于非典型的内在和先天防御。在本文中，我们回顾了这些非规范防御途径的研究以及疱疹病毒基因产物如何对抗它们，强调了体外初级神经元模型对我们理解这一领域的贡献。
Neuroinvasive herpesviruses have evolved to efficiently infect and establish latency in neurons. The nervous system has limited capability to regenerate, so immune responses therein are carefully regulated to be nondestructive, with dependence on atypical intrinsic and innate defenses. In this article we review studies of some of these noncanonical defense pathways and how herpesvirus gene products counter them, highlighting the contributions that primary neuronal in vitro models have made to our understanding of this field.