A Case of Eosinophilic Pneumonia Successfully Treated with Suplatast Tosilate Alone
A Case of Eosinophilic Pneumonia Successfully Treated with Suplatast Tosilate Alone
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DOI：
10.1159/000211380
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Fukuda, Takeshi
中科院分区：
文献类型：
--
作者：
Watanabe, Naoto;Hirata, Akira;Fukuda, Takeshi
我们报告一例嗜酸性粒细胞性肺炎，成功地治疗与甲磺司特。一位72岁的女性，患有高血压和糖尿病，不吸烟，不养宠物，以咳嗽、咳痰和轻微发热为主诉咨询医生。胸部X线片显示双侧上叶有渗透阴影。她去了医院，因为她的症状没有改善。由于炎症反应升高，怀疑肺结核，开始抗结核治疗。随后，外周血中出现嗜酸性粒细胞增多。尽管停用每日药物（盐酸尼卡地平、喷替福林和盐酸噻氯匹定），但嗜酸性粒细胞增多症未改善，并在痰液样本中检出。她被诊断为肺浸润伴嗜酸性粒细胞增多综合征并住院。体格检查听诊未发现干鸣音或心脏杂音。实验室检查结果显示白细胞计数为21，300/μ l，嗜酸性粒细胞占细胞的66.3%。在纤维支气管镜下检查肺活检标本后，诊断为嗜酸性粒细胞性肺炎。停用抗结核药物后，给予甲磺酸舒普司特300 mg/d治疗4周后，症状消退，嗜酸性粒细胞增多改善至正常范围，痰中嗜酸性粒细胞消失，胸片渗透影消失。版权所有（c）2009 S. Karger AG，巴塞尔
We report a case of eosinophilic pneumonia that was successfully treated with suplatast tosilate. A 72-year-old woman with hypertension and diabetes, who did not smoke and did not have pets, consulted a physician with the chief complaints of cough, sputum, and slight fever. Chest X-ray films revealed a permeation shadow in the bilateral upper lobes. She visited a hospital because her symptoms did not improve. Pulmonary tuberculosis was suspected because of an elevated inflammatory reaction, and anti-tuberculosis treatment was started. Afterwards, eosinophilia appeared in the peripheral blood. Although daily drugs (nicardipine hydrochloride, pentoxifylline, and ticlopidine hydrochloride) were stopped, eosinophilia did not improve and was detected in a sputum sample. She was diagnosed with pulmonary infiltration with eosinophilia syndrome and hospitalized. Physical examination revealed neither rhonchus nor cardiac murmurs on auscultation. Laboratory findings showed a leukocyte count of 21,300/mu l, with eosinophils accounting for 66.3% of cells. A diagnosis of eosinophilic pneumonia was made after a lung biopsy specimen was examined under a bronchial fiberscope. After suspension of anti-tuberculosis drugs and administration of suplatast tosilate 300 mg/day for 4 weeks, symptoms subsided, eosinophilia improved to within normal ranges, eosinophils in sputum disappeared, and the permeation shadow disappeared on chest X-ray films. Copyright (c) 2009 S. Karger AG, Basel