Platelet adhesion on silicon modified hydrogenated amorphous carbon films.
Platelet adhesion on silicon modified hydrogenated amorphous carbon films.
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DOI：
10.1016/s0142-9612(03)00494-0
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发表时间：
2004
期刊：
影响因子：
14
通讯作者：
T. Okpalugo;A. Ogwu;P. Maguire;J. McLaughlin
中科院分区：
文献类型：
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作者：
T. Okpalugo;A. Ogwu;P. Maguire;J. McLaughlin
我们研究了硅修饰的氢化非晶碳膜（a-C:H:Si或Si- dlc）的微观结构、表面能、表面电荷条件和电子传导的变化对人血小板与硅修饰的氢化非晶碳膜相互作用的影响。基于拉曼光谱、扫描电镜、x射线光电子能谱、表面能测量、电阻率、接触电位差和热退火的结果表明，一些测量值与薄膜与人体血小板的相互作用之间存在相关性。利用学生t检验对膜上的血小板聚集进行统计分析表明，改性膜上的血小板聚集与沉积膜上的血小板聚集差异在p值<0.05。
We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.