Molecular population genetics of the distal portion of the X chromosome in Drosophila: evidence for genetic hitchhiking of the yellow-achaete region.
Molecular population genetics of the distal portion of the X chromosome in Drosophila: evidence for genetic hitchhiking of the yellow-achaete region.
复制标题
果蝇 X 染色体远端部分的分子群体遗传学：黄果树区域遗传搭便车的证据。
DOI：
10.1093/genetics/129.4.1147
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发表时间：
1991
期刊：
影响因子：
3.3
通讯作者：
Aquadro,CF
中科院分区：
文献类型：
--
作者：
Begun,DJ;Aquadro,CF
我们估计DNA序列的变化和分化内和之间的黑腹果蝇和它的兄弟物种，果蝇simulans，使用六切割酶限制性位点的变化，在黄色achaete（γ-ac），磷酸葡萄糖酸脱氢酶（PGD），和周期（每）。这三个基因区域与X染色体端粒的距离不同，在D.黑腹菌根据Tajima的中性检验，Pgd区在D.黑腹菌这与之前的数据一致，表明该位点的同工酶多态性对选择是可见的。中性的哈德逊，Kreitman，Aguadé测试表明，与D中的per或rosy区域相比，y-ac区域显著偏离中性。simulans。与D.黑腹菌在这两个物种的偏离似乎是由于减少变化在y-ac相比，预期从D之间的分歧。simulans和D.黑腹菌我们的结论是，最近搭便车与一个或多个有利的突变体在y-ac区域的选择性固定是最好的解释减少变异y-ac。
We have estimated DNA sequence variation and differentiation within and between Drosophila melanogaster and its sibling species, Drosophila simulans, using six-cutter restriction site variation at yellow-achaete (y-ac), phosphogluconate dehydrogenase (Pgd), and period (per). These three gene regions are of varying distance from the telomere of the X chromosome and range from very low to moderate rates of recombination in D. melanogaster. According to Tajima's test of neutrality, the Pgd region has been influenced by balancing selection in D. melanogaster. This is consistent with previous data suggesting the allozyme polymorphism at this locus is visible to selection. The Hudson, Kreitman, Aguadé test of neutrality reveals a significant departure from neutrality for the y-ac region compared to the per or rosy regions in D. simulans. There is also a significant departure for the y-ac region compared to the Adh 5' flanking region in D. melanogaster. In both species the departure appears to be due to reduced variation at y-ac compared to that expected from divergence between D. simulans and D. melanogaster. We conclude that recent hitchhiking associated with the selective fixation of one or more advantageous mutants in the y-ac region is the best explanation for reduced variation at y-ac.