Methods for Using the Galleria mellonella Invertebrate Model to Probe Enterococcus faecalis Pathogenicity.
Methods for Using the Galleria mellonella Invertebrate Model to Probe Enterococcus faecalis Pathogenicity.
复制标题
使用大蜡螟无脊椎动物模型探测粪肠球菌致病性的方法。
DOI：
10.1007/978-1-0716-1971-1_15
复制
发表时间：
2022
期刊：
影响因子：
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通讯作者：
Lemos,JoséA
中科院分区：
文献类型：
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作者：
Lam,LingNing;Brunson,DebraN;Kajfasz,JessicaK;Lemos,JoséA
The Enterococci, mainlyEnterococcus faecalisandE. faecium, are ubiquitous members of the human gastrointestinal tract consortia but also a leading cause of opportunistic infections. The global rise in human-associated enterococcal infections, often caused by multidrug resistant strains, highlights an urgent need to identify the bacterial factors contributing to its pathogenicity such that new therapies can be devised. The use of theGalleria mellonella(greater wax moth) larvae, commonly known as wax worm, as a model to study host-pathogen interactions has allowed the identification and characterization of numerous bacterial factors that contribute to disease in humans, serving both as an alternative and complementary approach to mammalian models. Here, we describe the methods for usingG. mellonellato characterize the virulence factors ofE. faecalis.
