Differential secretion of catecholamine and neuropeptide y in response to KCl from mice chromaffin cells
Differential secretion of catecholamine and neuropeptide y in response to KCl from mice chromaffin cells
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DOI：
10.1111/j.1749-6632.2002.tb04489.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Grouzmann, E
中科院分区：
文献类型：
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作者：
Cavadas, C;Silva, AP;Grouzmann, E
嗜铬细胞以组成性和受调节的方式释放儿茶酚胺和无数肽，但在小鼠中没有关于响应于秘密激动剂同时释放的儿茶酚胺与肽的比率的数据。本研究的目的是检测培养的小鼠肾上腺嗜铬细胞是否对KCl去极化有不同的释放去甲肾上腺素（NE）、肾上腺素（EP）和神经肽Y（NPY）的反应。
Catecholamines and a myriad of peptides are released by chromaffin cells in a constitutive and regulated manner, but no data are available in mice on the ratio of catecholamines to peptides that are released simultaneously in response to a secret agogue. The goal of this investigation was to examine whether mouse adrenal chro maffin cells in culture released norepinephrine (NE), epinephrine (EP), and neuropeptide Y (NPY) differentially in response to depolarization by KCl.