Hydroxyurea Use Associated with Nonverbal and Executive Skills in Sickle Cell Anemia.
Hydroxyurea Use Associated with Nonverbal and Executive Skills in Sickle Cell Anemia.
复制标题
羟基脲的使用与镰状细胞性贫血的非语言和执行技能相关。
DOI：
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发表时间：
2021
影响因子：
3.6
通讯作者：
N. Apollonsky
中科院分区：
文献类型：
--
作者：
R. Tarazi;K. Patrick;Mary C. Iampietro;N. Apollonsky
客观的
OBJECTIVE
Hydroxyurea (HU) is used in children with sickle cell disease (SCD) to increase fetal hemoglobin (HF), contributing to a decrease in physical symptoms and potential protection against cerebral microvasculopathy. There has been minimal investigation into the association between HU use and cognition in this population. This study examined the relationship between HU status and cognition in children with SCD.
METHODS
Thirty-seven children with SCD HbSS or HbS/β0 thalassaemia (sickle cell anemia; SCA) ages 4:0-11 years with no history of overt stroke or chronic transfusion completed a neuropsychological test battery. Other medical, laboratory, and demographic data were obtained. Neuropsychological function across 3 domains (verbal, nonverbal, and attention/executive) was compared for children on HU (n = 9) to those not taking HU (n = 28).
RESULTS
Children on HU performed significantly better than children not taking HU on standardized measures of attention/executive functioning and nonverbal skills. Performance on verbal measures was similar between groups.
CONCLUSIONS
These results suggest that treatment with HU may not only reduce physical symptoms, but may also provide potential benefit to cognition in children with SCA, particularly in regard to attention/executive functioning and nonverbal skills. Replication with larger samples and longitudinal studies are warranted.
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影响因子：
15.9
作者：
PLATT, OS;ORKIN, SH;NATHAN, DG
通讯作者：
NATHAN, DG
胎儿血红蛋白、镰状细胞病和镰状细胞病。
影响因子：
--
作者：
Charache,S
通讯作者：
Charache,S
血红蛋白 SS 镰状细胞病儿童的认知障碍：与 MR 成像结果和血细胞比容的关系。
DOI：
--
发表时间：
2003
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Steen,RGrant;Miles,MarkA;Helton,KathleenJ;Strawn,Susan;Wang,Winfred;Xiong,Xiaoping;Mulhern,RaymondK
通讯作者：
Mulhern,RaymondK
影响因子：
158.5
作者：
CHARACHE, S;TERRIN, ML;WACLAWIW, M
通讯作者：
WACLAWIW, M
影响因子：
20.3
作者：
Fields, Melanie E.;Guilliams, Kristin P.;Ford, Andria L.
通讯作者：
Ford, Andria L.