Activity of ventrolateral thalamic neurons during arm movement.
Activity of ventrolateral thalamic neurons during arm movement.
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手臂运动期间腹外侧丘脑神经元的活动。
DOI：
10.1152/jn.1976.39.5.1032
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发表时间：
1976
影响因子：
2.5
通讯作者：
P. Strick
中科院分区：
文献类型：
--
作者：
P. Strick
1. 猴子被训练在一个小区域内保持手柄的操作，尽管手柄受到干扰，并在视觉刺激下进行缓慢和快速的手臂运动。然后在任务执行期间和被动操纵动物肢体时，检查直接投射到运动皮层手臂区域（VL手臂区域）的丘脑腹外侧区域的神经元活动。2. 与手臂运动相关的丘脑单元局限于左臂区域。在某些情况下，左臂区域的微刺激（小于25mua）可以引起肩部、手臂和手部肌肉组织的局部收缩。丘脑单元的放电似乎与下颚、舌头和颈部肌肉活动有关，仅发生在与手臂运动相关的内侧单元，而与自发腿部运动相关的单元仅发生在外侧。3. 大多数VL臂区神经元，尽管与主动手臂运动密切相关，但不受动物肢体的温和被动操作的影响。很少有VL臂区神经元在短潜伏期内对动物所持手柄的扰动作出反应。因此，VL臂区神经元与许多运动皮质臂区神经元不同，后者对被动操作有反应，并在短潜伏期内受到类似动物肢体的扰动的影响。4. 大多数与手臂运动相关的VL神经元在快速和缓慢的手臂运动中都放电。尽管少数神经元仅在快速运动时改变放电，但没有一个神经元仅在慢速运动时改变放电。因此，VL臂区神经元不同于其输入源之一苍白球的神经元，苍白球的一些神经元优先与慢速运动相关。5. 在快速和缓慢的运动中，在肌肉活动发生任何变化之前，一些VL臂区域神经元的放电会发生变化。这些神经元被记录在VL区域，它投射到代表近端和远端肌肉组织的运动皮层区域。这表明，VL神经元可能在与控制身体姿势有关的肌肉活动的启动中发挥作用，以及那些涉及离散肢体运动的肌肉
1. Monkeys were trained to maintain the handle of a manipulation within a small zone despite perturbations to the handle and to perform slow and rapid arm movements triggered by a visual stimulus. The activity of neurons in the region of the ventrolateral thalamus which projects directly to the arm area of the motor cortex (VL arm area) was then examined during performance of the task and while the animal's limb was passively manipulated. 2. Thalamic units related to arm movement were confined to the VL arm area. Microstimulation (less than 25 muA) in the VL arm area could, in some instances, evoke localized contractions of shoulder, arm, and hand musculature. Thalamic units whose discharge appeared to be related to jaw, tongue, and neck muscle activity occurred only medial to arm movement-related units, and units related to spontaneous leg movements occurred only laterally. 3. Most VL arm area neurons, although well related to active arm movements, were not influenced by gentle passive manipulation of the animal's limb. Few VL arm area neurons responded at short latency to perturbations applied to the handle of the manipulandum which the animal was holding. Thus, VL arm area neurons are unlike many motor cortex arm area neurons which are responsive to passive manipulation and are influenced at short latency by similar perturbations to the animal's limb. 4. Most arm movement-related VL neurons discharge during both fast and slow arm movements. Although a few neurons varied their discharge only during fast movements, none varied only in relation to slow movements. VL arm area neurons are, therefore, unlike the neurons in one source of its input, the globus pallidus, where some neurons are preferentially related to slow movements. 5. Some VL arm area neurons vary their discharge before any change in muscle activity during a fast and slow movement. Such neurons were recorded in VL regions which project to motor cortex areas representing proximal and distal musculature. This suggests that VL neurons might play a role in initiating activity in muscles concerned with controlling body posture, as well as those involved in discrete limb movements.20