Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.
Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.
复制标题
轻松制造具有可调释放动力学的聚酐/麻醉纳米颗粒。
DOI：
10.1002/adhm.201300521
复制
发表时间：
2014
影响因子：
10
通讯作者：
Laurencin,CatoT
中科院分区：
文献类型：
--
作者：
Ulery,BretD;Kan,Ho-Man;Williams,BryceA;Narasimhan,Balaji;Lo,KevinW-H;Nair,LakshmiS;Laurencin,CatoT
这项工作说明了一个两步的策略，用于制造聚合物/药物纳米颗粒。利用溶剂/非溶剂沉淀和气体碱化，制备了0-100%载药量的复合纳米粒。药物释放动力学由纳米颗粒组合物决定，从而允许将来针对治疗应用进行调整。
This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0–100% drug loadings were fabricated. Drug release kinetics were dictated by nanoparticle composition allowing for future tuning for therapeutic applications.