Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases.
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases.
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DOI：
10.3389/fpls.2014.00190
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发表时间：
2014
影响因子：
5.6
通讯作者：
Baena-González E
中科院分区：
文献类型：
--
作者：
Crozet P;Margalha L;Confraria A;Rodrigues A;Martinho C;Adamo M;Elias CA;Baena-González E
SNF 1（蔗糖非发酵1）相关蛋白激酶1（SnRKs 1）是芽殖酵母SNF 1和哺乳动物AMPK（AMP活化蛋白激酶）的植物直系同源物。这些进化上保守的激酶是代谢传感器，其响应于降低的能量水平而经历激活。激活后，SNF 1/AMPK/SnRK 1激酶触发大量的转录和代谢重编程，恢复能量稳态，促进对不利条件的耐受性，部分通过诱导分解代谢过程和一般抑制抗衰老。这些激酶通常作为由两个调节亚基β和γ以及α-催化亚基组成的异源三聚体复合物起作用，其需要保守活化环残基的磷酸化以获得活性。此外，SNF 1/AMPK/SnRK 1激酶受多种机制控制，这些机制对激酶活性、稳定性和/或亚细胞定位有影响。在这里，我们将审查目前的知识SNF 1/AMPK/SnRK 1的上游组件，翻译后修饰，各种代谢产物，激素，和其他的调节，试图突出这些重要的真核生物激酶的共性和分歧，已经发展到科普这些系统中的每一个的特殊性。
The SNF1 (sucrose non-fermenting 1)-related protein kinases 1 (SnRKs1) are the plant orthologs of the budding yeast SNF1 and mammalian AMPK (AMP-activated protein kinase). These evolutionarily conserved kinases are metabolic sensors that undergo activation in response to declining energy levels. Upon activation, SNF1/AMPK/SnRK1 kinases trigger a vast transcriptional and metabolic reprograming that restores energy homeostasis and promotes tolerance to adverse conditions, partly through an induction of catabolic processes and a general repression of anabolism. These kinases typically function as a heterotrimeric complex composed of two regulatory subunits, β and γ, and an α-catalytic subunit, which requires phosphorylation of a conserved activation loop residue for activity. Additionally, SNF1/AMPK/SnRK1 kinases are controlled by multiple mechanisms that have an impact on kinase activity, stability, and/or subcellular localization. Here we will review current knowledge on the regulation of SNF1/AMPK/SnRK1 by upstream components, post-translational modifications, various metabolites, hormones, and others, in an attempt to highlight both the commonalities of these essential eukaryotic kinases and the divergences that have evolved to cope with the particularities of each one of these systems.
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影响因子：
4.1
作者：
Al-Hakim, Abdallah K.;Zagorska, Anna;Alessi, Dario R.
通讯作者：
Alessi, Dario R.
影响因子：
3.5
作者：
CARLING, D;ZAMMIT, VA;HARDIE, DG
通讯作者：
HARDIE, DG
影响因子：
4.8
作者：
Ashrafi, K;Farazi, TA;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
4.3
作者：
Chen, Zhiyu;Shen, Xiaolu;Lai, Jiang
通讯作者：
Lai, Jiang
影响因子：
7.4
作者：
Ananieva, Elitsa A.;Gillaspy, Glenda E.;Erickson, F. Les
通讯作者：
Erickson, F. Les